Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma

BACKGROUND: Fibroblast growth factor receptor 2 (FGFR2) genetic alterations lead to tumor cell proliferation in various types of cancer. We hypothesized that FGFR2 amplification is associated with FGFR2 expression, resulting in tumor growth and poorer outcome in esophagogastric junction (EGJ) adenoc...

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Detalles Bibliográficos
Autores principales: Tokunaga, Ryuma, Imamura, Yu, Nakamura, Kenichi, Ishimoto, Takatsugu, Nakagawa, Shigeki, Miyake, Keisuke, Nakaji, Yu, Tsuda, Yasuo, Iwatsuki, Masaaki, Baba, Yoshifumi, Sakamoto, Yasuo, Miyamoto, Yuji, Saeki, Hiroshi, Yoshida, Naoya, Oki, Eiji, Watanabe, Masayuki, Oda, Yoshinao, Bass, Adam J., Maehara, Yoshihiko, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991416/
https://www.ncbi.nlm.nih.gov/pubmed/26933914
http://dx.doi.org/10.18632/oncotarget.7782

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