Cargando…

CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment

Liver cancer stem cells (CSCs) are resistant to conventional chemotherapy and radiation, which may destroy tumor masses, but not all liver CSCs contribute to tumor initiation, metastasis, and relapse. In the present study, we showed that liver CSCs with elevated Wnt/β-catenin signaling possess much...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Ji-Young, Lee, Hwa-Yong, Park, Kwan-Kyu, Choi, Yang-Kyu, Nam, Jeong-Seok, Hong, In-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991463/ https://www.ncbi.nlm.nih.gov/pubmed/26967248 http://dx.doi.org/10.18632/oncotarget.7954

Ejemplares similares

Wnt/β-Catenin Inhibition by CWP232291 as a Novel Therapeutic Strategy in Ovarian Cancer
por: Wang, Wenyu, et al.
Publicado: (2022)

Wnt/β-Catenin Signaling in Liver Cancers
por: Wang, Wenhui, et al.
Publicado: (2019)

The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway
por: Pak, Sahyun, et al.
Publicado: (2019)

Correction to: The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway
por: Pak, Sahyun, et al.
Publicado: (2019)

DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer
por: Kim, Hwa Jin, et al.
Publicado: (2018)

The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells
por: Dong, Hye-Jin, et al.
Publicado: (2016)

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway
por: Jeong, Woo-Jeong, et al.
Publicado: (2018)

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells
por: Wang, Ronghua, et al.
Publicado: (2015)

Constitutive expression of Wnt/β-catenin target genes promotes proliferation and invasion of liver cancer stem cells
por: CHEN, WEI, et al.
Publicado: (2016)

Cepharanthine hydrochloride inhibits the Wnt/β-catenin/Hedgehog signaling axis in liver cancer
por: Su, Gui-Feng, et al.
Publicado: (2022)

Infectious Agents Induce Wnt/β-Catenin Pathway Deregulation in Primary Liver Cancers
por: Catalano, Teresa, et al.
Publicado: (2023)

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway
por: Burke, Zoë D., et al.
Publicado: (2018)

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
por: Valkenburg, Kenneth C., et al.
Publicado: (2011)

Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis
por: Debebe, A, et al.
Publicado: (2017)

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype
por: Jang, Gyu-Beom, et al.
Publicado: (2015)

Targeting Wnt/β-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents
por: Selvaggi, Federico, et al.
Publicado: (2022)

Targeting the Wnt/β-Catenin Signaling Pathway in Liver Cancer Stem Cells and Hepatocellular Carcinoma Cell Lines with FH535
por: Gedaly, Roberto, et al.
Publicado: (2014)

miR‑122/SENP1 axis confers stemness and chemoresistance to liver cancer through Wnt/β‑catenin signaling
por: Dai, Jianbo, et al.
Publicado: (2023)

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics
por: Pandey, Pratibha, et al.
Publicado: (2023)

Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer
por: Chen, Jiayu, et al.
Publicado: (2020)

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
por: Kim, Hyun-Taek, et al.
Publicado: (2017)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway
por: Burke, Zoë D., et al.
Publicado: (2020)

Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer
por: Lee, Hwa-Yong, et al.
Publicado: (2020)

Therapeutic strategies targeting Wnt/β-catenin signaling for colorectal cancer (Review)
por: Ji, Yong, et al.
Publicado: (2022)

Low temperature upregulates cwp expression and modifies alternative splicing patterns, increasing the severity of cwp-induced tomato fruit cuticular microfissures
por: Chechanovsky, Noam, et al.
Publicado: (2019)

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver
por: Protiva, Petr, et al.
Publicado: (2015)

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer
por: Wei, Jinlai, et al.
Publicado: (2022)

Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
por: Vallée, Alexandre, et al.
Publicado: (2019)

Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells
por: Shim, Ah-Ram, et al.
Publicado: (2015)

Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway
por: Liang, Wei-Cheng, et al.
Publicado: (2019)

Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway
por: Liu, Xiaohan, et al.
Publicado: (2020)

ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling
por: Xu, Cong, et al.
Publicado: (2021)

Targeting the Wnt/β-catenin signaling pathway in cancer
por: Zhang, Ya, et al.
Publicado: (2020)

Wnt/β-catenin signaling in cancers and targeted therapies
por: Yu, Fanyuan, et al.
Publicado: (2021)

Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ β-catenin axis with subsequent inhibition of liver cancer stem cells
por: Zakaria, Sherin, et al.
Publicado: (2022)

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer
por: Ryu, Won-Ji, et al.
Publicado: (2020)

Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation
por: Preziosi, Morgan, et al.
Publicado: (2018)

A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver
por: Gougelet, Angélique, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pp0sqk82qno7qd75jlm7thfvtc