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Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer
Luminal breast cancer constitutes a group of highly heterogeneous diseases with a sustained high risk of late recurrence. We aimed to develop comprehensive and practical nomograms to better estimate the long-term survival of luminal breast cancer. Patients with luminal breast cancer diagnosed betwee...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991470/ https://www.ncbi.nlm.nih.gov/pubmed/26967253 http://dx.doi.org/10.18632/oncotarget.7975 |
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author | Sun, Wei Jiang, Yi-Zhou Liu, Yi-Rong Ma, Ding Shao, Zhi-Ming |
author_facet | Sun, Wei Jiang, Yi-Zhou Liu, Yi-Rong Ma, Ding Shao, Zhi-Ming |
author_sort | Sun, Wei |
collection | PubMed |
description | Luminal breast cancer constitutes a group of highly heterogeneous diseases with a sustained high risk of late recurrence. We aimed to develop comprehensive and practical nomograms to better estimate the long-term survival of luminal breast cancer. Patients with luminal breast cancer diagnosed between 1990 and 2006 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into the training (n = 87,867) and validation (n = 88,215) cohorts. The cumulative incidence function (CIF) and a competing-risks model were used to estimate the probability of breast cancer-specific survival (BCSS) and death from other causes. We integrated significant prognostic factors to build nomograms and subjected the nomograms to bootstrap internal validation and to external validation. We screened 176,082 luminal breast cancer cases. The 5- and 10-year probabilities of overall death were 0.089 and 0.202, respectively. The 5- and 10-year probabilities of breast cancer-specific mortality (BCSM) were 0.053 and 0.112, respectively. Nine independent prognostic factors for both OS and BCSS were integrated to construct the nomograms. The calibration curves for the probabilities of 5- and 10-year OS and BCSS showed excellent agreement between the nomogram prediction and actual observation. The C-indexes of the nomograms were high in both internal validation (0.732 for OS and 0.800 for BCSS) and external validation (0.731 for OS and 0.794 for BCSS). We established nomograms that accurately predict OS and BCSS for patients with luminal breast cancer. The nomograms can identify patients with higher risk of late overall mortality and BCSM, helping physicians in facilitating individualized treatment. |
format | Online Article Text |
id | pubmed-4991470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49914702016-09-01 Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer Sun, Wei Jiang, Yi-Zhou Liu, Yi-Rong Ma, Ding Shao, Zhi-Ming Oncotarget Research Paper Luminal breast cancer constitutes a group of highly heterogeneous diseases with a sustained high risk of late recurrence. We aimed to develop comprehensive and practical nomograms to better estimate the long-term survival of luminal breast cancer. Patients with luminal breast cancer diagnosed between 1990 and 2006 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into the training (n = 87,867) and validation (n = 88,215) cohorts. The cumulative incidence function (CIF) and a competing-risks model were used to estimate the probability of breast cancer-specific survival (BCSS) and death from other causes. We integrated significant prognostic factors to build nomograms and subjected the nomograms to bootstrap internal validation and to external validation. We screened 176,082 luminal breast cancer cases. The 5- and 10-year probabilities of overall death were 0.089 and 0.202, respectively. The 5- and 10-year probabilities of breast cancer-specific mortality (BCSM) were 0.053 and 0.112, respectively. Nine independent prognostic factors for both OS and BCSS were integrated to construct the nomograms. The calibration curves for the probabilities of 5- and 10-year OS and BCSS showed excellent agreement between the nomogram prediction and actual observation. The C-indexes of the nomograms were high in both internal validation (0.732 for OS and 0.800 for BCSS) and external validation (0.731 for OS and 0.794 for BCSS). We established nomograms that accurately predict OS and BCSS for patients with luminal breast cancer. The nomograms can identify patients with higher risk of late overall mortality and BCSM, helping physicians in facilitating individualized treatment. Impact Journals LLC 2016-03-07 /pmc/articles/PMC4991470/ /pubmed/26967253 http://dx.doi.org/10.18632/oncotarget.7975 Text en Copyright: © 2016 Sun et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Sun, Wei Jiang, Yi-Zhou Liu, Yi-Rong Ma, Ding Shao, Zhi-Ming Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title | Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title_full | Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title_fullStr | Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title_full_unstemmed | Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title_short | Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
title_sort | nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991470/ https://www.ncbi.nlm.nih.gov/pubmed/26967253 http://dx.doi.org/10.18632/oncotarget.7975 |
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