RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia

BCR/ABL is a well-known activator of multiple signaling pathways. RalA, a Ras downstream signaling molecule and a small GTPase, plays an important role in Bcr-Abl-induced leukemogenesis but the exact mechanism remains elusive. Here, we show that RalA GTPase activity is commonly high in chronic myelo...

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Detalles Bibliográficos
Autores principales: Gu, Chunming, Feng, Maoxiao, Yin, Zhao, Luo, Xiaochuang, Yang, Juhua, Li, Yumin, Li, Tianfu, Wang, Ruirui, Fei, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991475/
https://www.ncbi.nlm.nih.gov/pubmed/26967392
http://dx.doi.org/10.18632/oncotarget.7987

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