MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death. This high mortality has been commonly attributed to the presence of residual cancer stem cells (CSCs). Meanwhile, MEK1 signaling is regarded as a key molecular in HCC maintenance and development. However, nobody has figured o...

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Detalles Bibliográficos
Autores principales: Cheng, Jiamin, Liu, Chungang, Liu, Limei, Chen, Xuejiao, Shan, Juanjuan, Shen, Junjie, Zhu, Wei, Qian, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991478/
https://www.ncbi.nlm.nih.gov/pubmed/26967560
http://dx.doi.org/10.18632/oncotarget.7972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991478/
https://www.ncbi.nlm.nih.gov/pubmed/26967560
http://dx.doi.org/10.18632/oncotarget.7972

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