Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase, induces mitochondrial injury and apoptosis in human leukemia cells through the mitochondrial translocation of cofilin. Only dephosphorylated cofilin could translocate to mitochondria during cerulenin-ind...

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Detalles Bibliográficos
Autores principales: Zhang, Yanhao, Fu, Ruoqiu, Liu, Yanxia, Li, Jing, Zhang, Hongwei, Hu, Xiaoye, Chen, Yibiao, Liu, Xin, Li, Yunong, Li, Ping, Liu, Ehu, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991482/
https://www.ncbi.nlm.nih.gov/pubmed/26967395
http://dx.doi.org/10.18632/oncotarget.7994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991482/
https://www.ncbi.nlm.nih.gov/pubmed/26967395
http://dx.doi.org/10.18632/oncotarget.7994

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