Cargando…

Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase, induces mitochondrial injury and apoptosis in human leukemia cells through the mitochondrial translocation of cofilin. Only dephosphorylated cofilin could translocate to mitochondria during cerulenin-ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yanhao, Fu, Ruoqiu, Liu, Yanxia, Li, Jing, Zhang, Hongwei, Hu, Xiaoye, Chen, Yibiao, Liu, Xin, Li, Yunong, Li, Ping, Liu, Ehu, Gao, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991482/ https://www.ncbi.nlm.nih.gov/pubmed/26967395 http://dx.doi.org/10.18632/oncotarget.7994

Ejemplares similares

The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin
por: Zheng, Yi, et al.
Publicado: (2018)

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
por: Li, Guobing, et al.
Publicado: (2014)

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis
por: Hu, Jinjiao, et al.
Publicado: (2020)

Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p
por: Chen, Yibiao, et al.
Publicado: (2018)

A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3
por: Fu, Ruoqiu, et al.
Publicado: (2018)

ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine
por: Hu, Jinjiao, et al.
Publicado: (2019)

Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin
por: Zhang, Lin, et al.
Publicado: (2021)

Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway
por: Li, Guo-bing, et al.
Publicado: (2013)

Masked cerulenin enables a dual-site selective protein crosslink
por: Jiang, Ziran, et al.
Publicado: (2023)

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage
por: Li, Yunong, et al.
Publicado: (2019)

Dephosphorylated cofilin expression is associated with poor prognosis in cases of human breast cancer: a tissue microarray analysis
por: Maimaiti, Yusufu, et al.
Publicado: (2016)

Direct Rho-associated kinase inhibiton induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells
por: Zhang, Zhiqun, et al.
Publicado: (2006)

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons
por: Cho, In Ha, et al.
Publicado: (2013)

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation
por: Li, Chunyan, et al.
Publicado: (2019)

Cerulenin Blockade of Fatty Acid Synthase Reverses Hepatic Steatosis in ob/ob Mice
por: Cheng, Gang, et al.
Publicado: (2013)

PTEN suppresses tumorigenesis by directly dephosphorylating Akt
por: Bu, Lang, et al.
Publicado: (2021)

Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis
por: Hu, Xiaoye, et al.
Publicado: (2018)

Optimization of lipid production by the oleaginous yeast Lipomyces starkeyi by random mutagenesis coupled to cerulenin screening
por: Tapia V, Eulalia, et al.
Publicado: (2012)

Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network
por: Zhang, Yanhao, et al.
Publicado: (2019)

Regulation of Neurite Growth by Inorganic Pyrophosphatase 1 via JNK Dephosphorylation
por: Tezuka, Yu, et al.
Publicado: (2013)

ALDH1L1 Inhibits Cell Motility Via Dephosphorylation of Cofilin by PP1 and PP2A
por: Oleinik, Natalia V., et al.
Publicado: (2010)

Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation
por: Liu, Tian, et al.
Publicado: (2017)

Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor
por: Porrini, Lucía, et al.
Publicado: (2014)

Cofilin 2 in Serum as a Novel Biomarker for Alzheimer’s Disease in Han Chinese
por: Sun, Yingni, et al.
Publicado: (2019)

Hypoxia‐induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway
por: Yao, Bowen, et al.
Publicado: (2021)

Effect of cerulenin on fatty acid composition and gene expression pattern of DHA-producing strain Colwellia psychrerythraea strain 34H
por: Wan, Xia, et al.
Publicado: (2016)

MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation
por: Qi, Chenxiang, et al.
Publicado: (2021)

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets
por: Yue, Lambert, et al.
Publicado: (2020)

GFP Scaffold-Based Engineering for the Production of Unbranched Very Long Chain Fatty Acids in Escherichia coli With Oleic Acid and Cerulenin Supplementation
por: Kassab, Elias, et al.
Publicado: (2019)

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
por: Zhang, Yan, et al.
Publicado: (2015)

Cofilin Oligomer Formation Occurs In Vivo and Is Regulated by Cofilin Phosphorylation
por: Goyal, Pankaj, et al.
Publicado: (2013)

Berberine promotes nerve regeneration through IGFR-mediated JNK-AKT signal pathway
por: Zhang, Hai-Na, et al.
Publicado: (2018)

Role of Cofilin in Alzheimer’s Disease
por: Wang, Qiang, et al.
Publicado: (2020)

Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells
por: Wabnitz, G H, et al.
Publicado: (2010)

Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
por: Xu, Jing, et al.
Publicado: (2021)

Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways
por: Gu, Jing, et al.
Publicado: (2011)

De novo genome assembly and annotation of rice sheath rot fungus Sarocladium oryzae reveals genes involved in Helvolic acid and Cerulenin biosynthesis pathways
por: Hittalmani, Shailaja, et al.
Publicado: (2016)

Diallyl disulfide induces downregulation and inactivation of cofilin 1 differentiation via the Rac1/ROCK1/LIMK1 pathway in leukemia cells
por: Ling, Hui, et al.
Publicado: (2020)

Effect of HSP27 and Cofilin in the injury of hypoxia/reoxygenation on hepatocyte membrane F-actin microfilaments
por: Zhang, Yafei, et al.
Publicado: (2017)

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bfvfo9u38lmuf2j49am5474ai2