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Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system

PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.00...

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Autores principales: Li, Zai-Shang, Chen, Peng, Yao, Kai, Wang, Bin, Li, Jing, Mi, Qi-Wu, Chen, Xiao-Feng, Zhao, Qi, Li, Yong-Hong, Chen, Jie-Ping, Deng, Chuang-Zhong, Ye, Yun-Lin, Zhong, Ming-Zhu, Liu, Zhuo-Wei, Qin, Zi-Ke, Lin, Xiang-Tian, Liang, Wei-Cong, Han, Hui, Zhou, Fang-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991509/
https://www.ncbi.nlm.nih.gov/pubmed/26980738
http://dx.doi.org/10.18632/oncotarget.8037
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author Li, Zai-Shang
Chen, Peng
Yao, Kai
Wang, Bin
Li, Jing
Mi, Qi-Wu
Chen, Xiao-Feng
Zhao, Qi
Li, Yong-Hong
Chen, Jie-Ping
Deng, Chuang-Zhong
Ye, Yun-Lin
Zhong, Ming-Zhu
Liu, Zhuo-Wei
Qin, Zi-Ke
Lin, Xiang-Tian
Liang, Wei-Cong
Han, Hui
Zhou, Fang-Jian
author_facet Li, Zai-Shang
Chen, Peng
Yao, Kai
Wang, Bin
Li, Jing
Mi, Qi-Wu
Chen, Xiao-Feng
Zhao, Qi
Li, Yong-Hong
Chen, Jie-Ping
Deng, Chuang-Zhong
Ye, Yun-Lin
Zhong, Ming-Zhu
Liu, Zhuo-Wei
Qin, Zi-Ke
Lin, Xiang-Tian
Liang, Wei-Cong
Han, Hui
Zhou, Fang-Jian
author_sort Li, Zai-Shang
collection PubMed
description PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). The 3-year DSS was 86.5% in patients with a BMI < 22.6 Kg/m2 and 69.9% in those with a higher BMI (P = 0.025). In a multivariate analysis, pathological T stage (P < 0.001), pathological N stage (P = 0.002), BMI (P = 0.002), and CRP (P = 0.004) were independent predictors of DSS. A new scoring model was developed, consisting of BMI, CRP, and tumor T and N classification. In our study, we found that the addition of the above-mentioned parameters significantly increased the predictive accuracy of the system of the American Joint Committee on Cancer (AJCC) anatomic stage group. The accuracy of the new prediction category was verified. METHODS: A total of 172 Chinese patients with penile squamous cell cancer were analyzed retrospectively between November 2005 and November 2014. Statistical data analysis was conducted using the nonparametric method. Survival analysis was performed with the log-rank test and the Cox proportional hazard model. Based on regression estimates of significant parameters in multivariate analysis, a new BMI-, CRP- and pathologic factors-based scoring model was developed to predict disease-specific outcomes. The predictive accuracy of the model was evaluated using the internal and external validation. CONCLUSION: The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients.
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spelling pubmed-49915092016-09-01 Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system Li, Zai-Shang Chen, Peng Yao, Kai Wang, Bin Li, Jing Mi, Qi-Wu Chen, Xiao-Feng Zhao, Qi Li, Yong-Hong Chen, Jie-Ping Deng, Chuang-Zhong Ye, Yun-Lin Zhong, Ming-Zhu Liu, Zhuo-Wei Qin, Zi-Ke Lin, Xiang-Tian Liang, Wei-Cong Han, Hui Zhou, Fang-Jian Oncotarget Clinical Research Paper PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). The 3-year DSS was 86.5% in patients with a BMI < 22.6 Kg/m2 and 69.9% in those with a higher BMI (P = 0.025). In a multivariate analysis, pathological T stage (P < 0.001), pathological N stage (P = 0.002), BMI (P = 0.002), and CRP (P = 0.004) were independent predictors of DSS. A new scoring model was developed, consisting of BMI, CRP, and tumor T and N classification. In our study, we found that the addition of the above-mentioned parameters significantly increased the predictive accuracy of the system of the American Joint Committee on Cancer (AJCC) anatomic stage group. The accuracy of the new prediction category was verified. METHODS: A total of 172 Chinese patients with penile squamous cell cancer were analyzed retrospectively between November 2005 and November 2014. Statistical data analysis was conducted using the nonparametric method. Survival analysis was performed with the log-rank test and the Cox proportional hazard model. Based on regression estimates of significant parameters in multivariate analysis, a new BMI-, CRP- and pathologic factors-based scoring model was developed to predict disease-specific outcomes. The predictive accuracy of the model was evaluated using the internal and external validation. CONCLUSION: The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients. Impact Journals LLC 2016-03-11 /pmc/articles/PMC4991509/ /pubmed/26980738 http://dx.doi.org/10.18632/oncotarget.8037 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Li, Zai-Shang
Chen, Peng
Yao, Kai
Wang, Bin
Li, Jing
Mi, Qi-Wu
Chen, Xiao-Feng
Zhao, Qi
Li, Yong-Hong
Chen, Jie-Ping
Deng, Chuang-Zhong
Ye, Yun-Lin
Zhong, Ming-Zhu
Liu, Zhuo-Wei
Qin, Zi-Ke
Lin, Xiang-Tian
Liang, Wei-Cong
Han, Hui
Zhou, Fang-Jian
Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title_full Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title_fullStr Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title_full_unstemmed Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title_short Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
title_sort development of a new outcome prediction model for chinese patients with penile squamous cell carcinoma based on preoperative serum c-reactive protein, body mass index, and standard pathological risk factors: the tncb score group system
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991509/
https://www.ncbi.nlm.nih.gov/pubmed/26980738
http://dx.doi.org/10.18632/oncotarget.8037
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