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Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system
PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.00...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991509/ https://www.ncbi.nlm.nih.gov/pubmed/26980738 http://dx.doi.org/10.18632/oncotarget.8037 |
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author | Li, Zai-Shang Chen, Peng Yao, Kai Wang, Bin Li, Jing Mi, Qi-Wu Chen, Xiao-Feng Zhao, Qi Li, Yong-Hong Chen, Jie-Ping Deng, Chuang-Zhong Ye, Yun-Lin Zhong, Ming-Zhu Liu, Zhuo-Wei Qin, Zi-Ke Lin, Xiang-Tian Liang, Wei-Cong Han, Hui Zhou, Fang-Jian |
author_facet | Li, Zai-Shang Chen, Peng Yao, Kai Wang, Bin Li, Jing Mi, Qi-Wu Chen, Xiao-Feng Zhao, Qi Li, Yong-Hong Chen, Jie-Ping Deng, Chuang-Zhong Ye, Yun-Lin Zhong, Ming-Zhu Liu, Zhuo-Wei Qin, Zi-Ke Lin, Xiang-Tian Liang, Wei-Cong Han, Hui Zhou, Fang-Jian |
author_sort | Li, Zai-Shang |
collection | PubMed |
description | PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). The 3-year DSS was 86.5% in patients with a BMI < 22.6 Kg/m2 and 69.9% in those with a higher BMI (P = 0.025). In a multivariate analysis, pathological T stage (P < 0.001), pathological N stage (P = 0.002), BMI (P = 0.002), and CRP (P = 0.004) were independent predictors of DSS. A new scoring model was developed, consisting of BMI, CRP, and tumor T and N classification. In our study, we found that the addition of the above-mentioned parameters significantly increased the predictive accuracy of the system of the American Joint Committee on Cancer (AJCC) anatomic stage group. The accuracy of the new prediction category was verified. METHODS: A total of 172 Chinese patients with penile squamous cell cancer were analyzed retrospectively between November 2005 and November 2014. Statistical data analysis was conducted using the nonparametric method. Survival analysis was performed with the log-rank test and the Cox proportional hazard model. Based on regression estimates of significant parameters in multivariate analysis, a new BMI-, CRP- and pathologic factors-based scoring model was developed to predict disease-specific outcomes. The predictive accuracy of the model was evaluated using the internal and external validation. CONCLUSION: The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients. |
format | Online Article Text |
id | pubmed-4991509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49915092016-09-01 Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system Li, Zai-Shang Chen, Peng Yao, Kai Wang, Bin Li, Jing Mi, Qi-Wu Chen, Xiao-Feng Zhao, Qi Li, Yong-Hong Chen, Jie-Ping Deng, Chuang-Zhong Ye, Yun-Lin Zhong, Ming-Zhu Liu, Zhuo-Wei Qin, Zi-Ke Lin, Xiang-Tian Liang, Wei-Cong Han, Hui Zhou, Fang-Jian Oncotarget Clinical Research Paper PURPOSE: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. RESULTS: The 3-year disease-specific survival (DSS) was 92.3% in patients with < 8.70 mg/L CRP and 54.9% in those with elevated CRP (P < 0.001). The 3-year DSS was 86.5% in patients with a BMI < 22.6 Kg/m2 and 69.9% in those with a higher BMI (P = 0.025). In a multivariate analysis, pathological T stage (P < 0.001), pathological N stage (P = 0.002), BMI (P = 0.002), and CRP (P = 0.004) were independent predictors of DSS. A new scoring model was developed, consisting of BMI, CRP, and tumor T and N classification. In our study, we found that the addition of the above-mentioned parameters significantly increased the predictive accuracy of the system of the American Joint Committee on Cancer (AJCC) anatomic stage group. The accuracy of the new prediction category was verified. METHODS: A total of 172 Chinese patients with penile squamous cell cancer were analyzed retrospectively between November 2005 and November 2014. Statistical data analysis was conducted using the nonparametric method. Survival analysis was performed with the log-rank test and the Cox proportional hazard model. Based on regression estimates of significant parameters in multivariate analysis, a new BMI-, CRP- and pathologic factors-based scoring model was developed to predict disease-specific outcomes. The predictive accuracy of the model was evaluated using the internal and external validation. CONCLUSION: The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients. Impact Journals LLC 2016-03-11 /pmc/articles/PMC4991509/ /pubmed/26980738 http://dx.doi.org/10.18632/oncotarget.8037 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Li, Zai-Shang Chen, Peng Yao, Kai Wang, Bin Li, Jing Mi, Qi-Wu Chen, Xiao-Feng Zhao, Qi Li, Yong-Hong Chen, Jie-Ping Deng, Chuang-Zhong Ye, Yun-Lin Zhong, Ming-Zhu Liu, Zhuo-Wei Qin, Zi-Ke Lin, Xiang-Tian Liang, Wei-Cong Han, Hui Zhou, Fang-Jian Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title | Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title_full | Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title_fullStr | Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title_full_unstemmed | Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title_short | Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system |
title_sort | development of a new outcome prediction model for chinese patients with penile squamous cell carcinoma based on preoperative serum c-reactive protein, body mass index, and standard pathological risk factors: the tncb score group system |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991509/ https://www.ncbi.nlm.nih.gov/pubmed/26980738 http://dx.doi.org/10.18632/oncotarget.8037 |
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