Cargando…

Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents

[Image: see text] An open-source hyperpolarizer producing (13)C hyperpolarized contrast agents using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented. This PHIP hyperpolarizer utilizes an Arduino microcontroller in conjunction with a readily modified graphi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coffey, Aaron M., Shchepin, Roman V., Truong, Milton L., Wilkens, Ken, Pham, Wellington, Chekmenev, Eduard Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991553/ https://www.ncbi.nlm.nih.gov/pubmed/27478927 http://dx.doi.org/10.1021/acs.analchem.6b02130

Ejemplares similares

Propane-d(6) Heterogeneously Hyperpolarized by Parahydrogen
por: Kovtunov, Kirill V., et al.
Publicado: (2014)

Efficient Synthesis of Nicotinamide-1-(15)N for Ultrafast NMR Hyperpolarization Using Parahydrogen
por: Shchepin, Roman V., et al.
Publicado: (2016)

Demonstration of Heterogeneous Parahydrogen Induced Polarization Using Hyperpolarized Agent Migration from Dissolved Rh(I) Complex to Gas Phase
por: Kovtunov, Kirill V., et al.
Publicado: (2014)

Parahydrogen Induced Polarization of 1-(13)C-Phospholactate-d(2) for Biomedical Imaging with >30,000,000-fold NMR Signal Enhancement in Water
por: Shchepin, Roman V., et al.
Publicado: (2014)

Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
por: Colell, Johannes F. P., et al.
Publicado: (2017)

NMR SLIC Sensing of Hydrogenation Reactions Using Parahydrogen in Low Magnetic Fields
por: Barskiy, Danila A., et al.
Publicado: (2016)

Hyperpolarization of “Neat” Liquids by NMR Signal Amplification by Reversible Exchange
por: Shchepin, Roman V., et al.
Publicado: (2015)

(15)N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH
por: Truong, Milton L., et al.
Publicado: (2015)

Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-(13)C-Acetates and 1-(13)C-Pyruvates via Side Arm Hydrogenation
por: Chukanov, Nikita V., et al.
Publicado: (2018)

Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe
por: Barskiy, Danila A., et al.
Publicado: (2016)

(15)N Hyperpolarization of Imidazole-(15)N(2) for Magnetic Resonance pH Sensing via SABRE-SHEATH
por: Shchepin, Roman V., et al.
Publicado: (2016)

Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange
por: Truong, Milton L., et al.
Publicado: (2014)

Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives
por: Zlobina, Veronika V., et al.
Publicado: (2022)

Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives
por: Ausmees, Kerti, et al.
Publicado: (2022)

High-Resolution Low-Field Molecular Magnetic Resonance Imaging of Hyperpolarized Liquids
por: Coffey, Aaron M., et al.
Publicado: (2014)

The (13)C hyperpolarized pyruvate generated by ParaHydrogen detects the response of the heart to altered metabolism in real time
por: Cavallari, Eleonora, et al.
Publicado: (2018)

Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for Hyperpolarized (13)C MR Imaging
por: Stewart, Neil J., et al.
Publicado: (2019)

Strongly hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles
por: Sharma, Ramesh, et al.
Publicado: (2012)

Using parahydrogen to hyperpolarize amines, amides, carboxylic acids, alcohols, phosphates, and carbonates
por: Iali, Wissam, et al.
Publicado: (2018)

Hyperpolarization of cis‐(15)N(2)‐Azobenzene by Parahydrogen at Ultralow Magnetic Fields
por: Sheberstov, Kirill F., et al.
Publicado: (2021)

Hyperpolarization Effects in Parahydrogen Activation with Pnictogen Biradicaloids: Metal‐free PHIP and SABRE
por: Zhivonitko, Vladimir V., et al.
Publicado: (2021)

SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents
por: Duchowny, Anton, et al.
Publicado: (2023)

Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
por: Ellermann, Frowin, et al.
Publicado: (2023)

Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization
por: Theis, Thomas, et al.
Publicado: (2015)

Hyperpolarized (13)C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study
por: Stewart, Neil J., et al.
Publicado: (2021)

Spontaneous (15)N Nuclear Spin Hyperpolarization in Metal-Free Activation of Parahydrogen by Molecular Tweezers
por: Sorochkina, Kristina, et al.
Publicado: (2018)

Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
por: Sellies, Lisanne, et al.
Publicado: (2021)

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange
por: Kidd, Bryce E., et al.
Publicado: (2023)

Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer
por: Birchall, Jonathan R., et al.
Publicado: (2022)

NMR Discrimination of d- and l-α-Amino Acids at Submicromolar Concentration via Parahydrogen-Induced Hyperpolarization
por: Dreisewerd, Lennart, et al.
Publicado: (2023)

Reversible Parahydrogen Induced Hyperpolarization of (15)N in Unmodified Amino Acids Unraveled at High Magnetic Field
por: Vaneeckhaute, Ewoud, et al.
Publicado: (2023)

Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts
por: Shi, Fan, et al.
Publicado: (2016)

Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode (129)Xe Hyperpolarizers
por: Nikolaou, Panayiotis, et al.
Publicado: (2014)

PHIP hyperpolarized [1-(13)C]pyruvate and [1-(13)C]acetate esters via PH-INEPT polarization transfer monitored by (13)C NMR and MRI
por: Svyatova, Alexandra, et al.
Publicado: (2021)

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-(13)C]ketoisocaproate
por: Adelabu, Isaiah, et al.
Publicado: (2023)

Hyperpolarization of (15)N-pyridinium and (15)N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media
por: Jagtap, Anil P., et al.
Publicado: (2019)

Parahydrogen‐Induced Polarization of Amino Acids
por: Pravdivtsev, Andrey N., et al.
Publicado: (2021)

Spin Hyperpolarization in Modern Magnetic Resonance
por: Eills, James, et al.
Publicado: (2023)

Direct and indirect hyperpolarisation of amines using parahydrogen
por: Iali, Wissam, et al.
Publicado: (2018)

Lifetime of Parahydrogen in Aqueous Solutions and Human Blood
por: Schmidt, Andreas B., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oiqjrhtqem05e8c4jdesgpahoq