Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contri...

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Detalles Bibliográficos
Autores principales: Shen, Hua, Yu, Xiaobo, Yang, Fengming, Zhang, Zhihua, Shen, Jianxin, Sun, Jin, Choksi, Swati, Jitkaew, Siriporn, Shu, Yongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991802/
https://www.ncbi.nlm.nih.gov/pubmed/27541266
http://dx.doi.org/10.1371/journal.pgen.1006244

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