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Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill

A motor cortex-based brain-computer interface (BCI) creates a novel real world output directly from cortical activity. Use of a BCI has been demonstrated to be a learned skill that involves recruitment of neural populations that are directly linked to BCI control as well as those that are not. The n...

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Autores principales: Wander, Jeremiah D., Sarma, Devapratim, Johnson, Lise A., Fetz, Eberhard E., Rao, Rajesh P. N., Ojemann, Jeffrey G., Darvas, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991818/
https://www.ncbi.nlm.nih.gov/pubmed/27541829
http://dx.doi.org/10.1371/journal.pcbi.1004931
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author Wander, Jeremiah D.
Sarma, Devapratim
Johnson, Lise A.
Fetz, Eberhard E.
Rao, Rajesh P. N.
Ojemann, Jeffrey G.
Darvas, Felix
author_facet Wander, Jeremiah D.
Sarma, Devapratim
Johnson, Lise A.
Fetz, Eberhard E.
Rao, Rajesh P. N.
Ojemann, Jeffrey G.
Darvas, Felix
author_sort Wander, Jeremiah D.
collection PubMed
description A motor cortex-based brain-computer interface (BCI) creates a novel real world output directly from cortical activity. Use of a BCI has been demonstrated to be a learned skill that involves recruitment of neural populations that are directly linked to BCI control as well as those that are not. The nature of interactions between these populations, however, remains largely unknown. Here, we employed a data-driven approach to assess the interaction between both local and remote cortical areas during the use of an electrocorticographic BCI, a method which allows direct sampling of cortical surface potentials. Comparing the area controlling the BCI with remote areas, we evaluated relationships between the amplitude envelopes of band limited powers as well as non-linear phase-phase interactions. We found amplitude-amplitude interactions in the high gamma (HG, 70–150 Hz) range that were primarily located in the posterior portion of the frontal lobe, near the controlling site, and non-linear phase-phase interactions involving multiple frequencies (cross-frequency coupling between 8–11 Hz and 70–90 Hz) taking place over larger cortical distances. Further, strength of the amplitude-amplitude interactions decreased with time, whereas the phase-phase interactions did not. These findings suggest multiple modes of cortical communication taking place during BCI use that are specialized for function and depend on interaction distance.
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spelling pubmed-49918182016-09-12 Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill Wander, Jeremiah D. Sarma, Devapratim Johnson, Lise A. Fetz, Eberhard E. Rao, Rajesh P. N. Ojemann, Jeffrey G. Darvas, Felix PLoS Comput Biol Research Article A motor cortex-based brain-computer interface (BCI) creates a novel real world output directly from cortical activity. Use of a BCI has been demonstrated to be a learned skill that involves recruitment of neural populations that are directly linked to BCI control as well as those that are not. The nature of interactions between these populations, however, remains largely unknown. Here, we employed a data-driven approach to assess the interaction between both local and remote cortical areas during the use of an electrocorticographic BCI, a method which allows direct sampling of cortical surface potentials. Comparing the area controlling the BCI with remote areas, we evaluated relationships between the amplitude envelopes of band limited powers as well as non-linear phase-phase interactions. We found amplitude-amplitude interactions in the high gamma (HG, 70–150 Hz) range that were primarily located in the posterior portion of the frontal lobe, near the controlling site, and non-linear phase-phase interactions involving multiple frequencies (cross-frequency coupling between 8–11 Hz and 70–90 Hz) taking place over larger cortical distances. Further, strength of the amplitude-amplitude interactions decreased with time, whereas the phase-phase interactions did not. These findings suggest multiple modes of cortical communication taking place during BCI use that are specialized for function and depend on interaction distance. Public Library of Science 2016-08-19 /pmc/articles/PMC4991818/ /pubmed/27541829 http://dx.doi.org/10.1371/journal.pcbi.1004931 Text en © 2016 Wander et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wander, Jeremiah D.
Sarma, Devapratim
Johnson, Lise A.
Fetz, Eberhard E.
Rao, Rajesh P. N.
Ojemann, Jeffrey G.
Darvas, Felix
Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title_full Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title_fullStr Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title_full_unstemmed Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title_short Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill
title_sort cortico-cortical interactions during acquisition and use of a neuroprosthetic skill
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991818/
https://www.ncbi.nlm.nih.gov/pubmed/27541829
http://dx.doi.org/10.1371/journal.pcbi.1004931
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