Detection of a Yersinia pestis gene homologue in rodent samples

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. S...

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Autores principales: Giles, Timothy A., Greenwood, Alex D., Tsangaras, Kyriakos, Giles, Tom C., Barrow, Paul A., Hannant, Duncan, Abu-Median, Abu-Bakr, Yon, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991868/
https://www.ncbi.nlm.nih.gov/pubmed/27602258
http://dx.doi.org/10.7717/peerj.2216
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author Giles, Timothy A.
Greenwood, Alex D.
Tsangaras, Kyriakos
Giles, Tom C.
Barrow, Paul A.
Hannant, Duncan
Abu-Median, Abu-Bakr
Yon, Lisa
author_facet Giles, Timothy A.
Greenwood, Alex D.
Tsangaras, Kyriakos
Giles, Tom C.
Barrow, Paul A.
Hannant, Duncan
Abu-Median, Abu-Bakr
Yon, Lisa
author_sort Giles, Timothy A.
collection PubMed
description A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. Samples were from urban locations in the UK (Liverpool) and Canada (Vancouver). The results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of Yersinia pestis, so caution should be taken when using this gene as a diagnostic marker.
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spelling pubmed-49918682016-09-06 Detection of a Yersinia pestis gene homologue in rodent samples Giles, Timothy A. Greenwood, Alex D. Tsangaras, Kyriakos Giles, Tom C. Barrow, Paul A. Hannant, Duncan Abu-Median, Abu-Bakr Yon, Lisa PeerJ Genetics A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. Samples were from urban locations in the UK (Liverpool) and Canada (Vancouver). The results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of Yersinia pestis, so caution should be taken when using this gene as a diagnostic marker. PeerJ Inc. 2016-08-17 /pmc/articles/PMC4991868/ /pubmed/27602258 http://dx.doi.org/10.7717/peerj.2216 Text en ©2016 Giles et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Genetics
Giles, Timothy A.
Greenwood, Alex D.
Tsangaras, Kyriakos
Giles, Tom C.
Barrow, Paul A.
Hannant, Duncan
Abu-Median, Abu-Bakr
Yon, Lisa
Detection of a Yersinia pestis gene homologue in rodent samples
title Detection of a Yersinia pestis gene homologue in rodent samples
title_full Detection of a Yersinia pestis gene homologue in rodent samples
title_fullStr Detection of a Yersinia pestis gene homologue in rodent samples
title_full_unstemmed Detection of a Yersinia pestis gene homologue in rodent samples
title_short Detection of a Yersinia pestis gene homologue in rodent samples
title_sort detection of a yersinia pestis gene homologue in rodent samples
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991868/
https://www.ncbi.nlm.nih.gov/pubmed/27602258
http://dx.doi.org/10.7717/peerj.2216
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