PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind D...

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Detalles Bibliográficos
Autores principales: Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992063/
https://www.ncbi.nlm.nih.gov/pubmed/27530147
http://dx.doi.org/10.1038/ncomms12404

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