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Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992093/ https://www.ncbi.nlm.nih.gov/pubmed/27579449 http://dx.doi.org/10.1016/j.heliyon.2016.e00143 |
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author | Welinder, Charlotte Jirström, Karin Lehn, Sophie Nodin, Björn Marko-Varga, György Blixt, Ola Danielsson, Lena Jansson, Bo |
author_facet | Welinder, Charlotte Jirström, Karin Lehn, Sophie Nodin, Björn Marko-Varga, György Blixt, Ola Danielsson, Lena Jansson, Bo |
author_sort | Welinder, Charlotte |
collection | PubMed |
description | A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells. |
format | Online Article Text |
id | pubmed-4992093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49920932016-08-30 Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. Welinder, Charlotte Jirström, Karin Lehn, Sophie Nodin, Björn Marko-Varga, György Blixt, Ola Danielsson, Lena Jansson, Bo Heliyon Article A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells. Elsevier 2016-08-16 /pmc/articles/PMC4992093/ /pubmed/27579449 http://dx.doi.org/10.1016/j.heliyon.2016.e00143 Text en © 2016 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Welinder, Charlotte Jirström, Karin Lehn, Sophie Nodin, Björn Marko-Varga, György Blixt, Ola Danielsson, Lena Jansson, Bo Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title | Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title_full | Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title_fullStr | Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title_full_unstemmed | Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title_short | Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
title_sort | intra-tumour iga1 is common in cancer and is correlated with poor prognosis in bladder cancer. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992093/ https://www.ncbi.nlm.nih.gov/pubmed/27579449 http://dx.doi.org/10.1016/j.heliyon.2016.e00143 |
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