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Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large c...

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Autores principales: Welinder, Charlotte, Jirström, Karin, Lehn, Sophie, Nodin, Björn, Marko-Varga, György, Blixt, Ola, Danielsson, Lena, Jansson, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992093/
https://www.ncbi.nlm.nih.gov/pubmed/27579449
http://dx.doi.org/10.1016/j.heliyon.2016.e00143
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author Welinder, Charlotte
Jirström, Karin
Lehn, Sophie
Nodin, Björn
Marko-Varga, György
Blixt, Ola
Danielsson, Lena
Jansson, Bo
author_facet Welinder, Charlotte
Jirström, Karin
Lehn, Sophie
Nodin, Björn
Marko-Varga, György
Blixt, Ola
Danielsson, Lena
Jansson, Bo
author_sort Welinder, Charlotte
collection PubMed
description A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.
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spelling pubmed-49920932016-08-30 Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. Welinder, Charlotte Jirström, Karin Lehn, Sophie Nodin, Björn Marko-Varga, György Blixt, Ola Danielsson, Lena Jansson, Bo Heliyon Article A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells. Elsevier 2016-08-16 /pmc/articles/PMC4992093/ /pubmed/27579449 http://dx.doi.org/10.1016/j.heliyon.2016.e00143 Text en © 2016 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Welinder, Charlotte
Jirström, Karin
Lehn, Sophie
Nodin, Björn
Marko-Varga, György
Blixt, Ola
Danielsson, Lena
Jansson, Bo
Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title_full Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title_fullStr Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title_full_unstemmed Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title_short Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
title_sort intra-tumour iga1 is common in cancer and is correlated with poor prognosis in bladder cancer.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992093/
https://www.ncbi.nlm.nih.gov/pubmed/27579449
http://dx.doi.org/10.1016/j.heliyon.2016.e00143
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