Mechanosensing by the α(6)-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the basement membrane (BM). We identify α(6)-integrin as a mechanosensing integrin subunit that mediates matrix stiffnes...

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Detalles Bibliográficos
Autores principales: Chen, Huaping, Qu, Jing, Huang, Xiangwei, Kurundkar, Ashish, Zhu, Lanyan, Yang, Naiheng, Venado, Aida, Ding, Qiang, Liu, Gang, Antony, Veena B., Thannickal, Victor J., Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992155/
https://www.ncbi.nlm.nih.gov/pubmed/27535718
http://dx.doi.org/10.1038/ncomms12564

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