Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in α,β-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to access analogues of deoxyelephantopin, a sesquiterpen...

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Detalles Bibliográficos
Autores principales: Lagoutte, Roman, Serba, Christelle, Abegg, Daniel, Hoch, Dominic G., Adibekian, Alexander, Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992173/
https://www.ncbi.nlm.nih.gov/pubmed/27539788
http://dx.doi.org/10.1038/ncomms12470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992173/
https://www.ncbi.nlm.nih.gov/pubmed/27539788
http://dx.doi.org/10.1038/ncomms12470

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