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2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer

BACKGROUND: 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a heterocyclic aromatic amine (HCA) formed in meat that is cooked at high temperatures and then ingested, can potentially be retained in human adipose tissues. METHODS: To determine if PhIP is bioactive in the adipocyte, we exposed...

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Detalles Bibliográficos
Autores principales:	Rogers, Lora J., Basnakian, Alexei G., Orloff, Mohammed S., Ning, Baitang, Yao-Borengasser, Aiwei, Raj, Vinay, Kadlubar, Susan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992261/ https://www.ncbi.nlm.nih.gov/pubmed/27547236 http://dx.doi.org/10.1186/s12986-016-0111-0

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