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Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue

The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the M...

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Autores principales: Pokryszko-Dragan, Anna, Zagrajek, Mieszko, Slotwinski, Krzysztof, Bilinska, Malgorzata, Gruszka, Ewa, Podemski, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992503/
https://www.ncbi.nlm.nih.gov/pubmed/27271940
http://dx.doi.org/10.1007/s10072-016-2622-x
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author Pokryszko-Dragan, Anna
Zagrajek, Mieszko
Slotwinski, Krzysztof
Bilinska, Malgorzata
Gruszka, Ewa
Podemski, Ryszard
author_facet Pokryszko-Dragan, Anna
Zagrajek, Mieszko
Slotwinski, Krzysztof
Bilinska, Malgorzata
Gruszka, Ewa
Podemski, Ryszard
author_sort Pokryszko-Dragan, Anna
collection PubMed
description The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the Modified Fatigue Impact Scale (MFIS/MFISmod). N200 and P300 components of auditory ERP were analyzed. Cognition was evaluated by means of Brief Repeatable Battery of Neuropsychological Tests (BRBNT). The results of ERP and BRBNT were compared between non-fatigued, moderately and severely fatigued MS patients and controls. P300 latency was significantly longer in the whole MS group and in the fatigued patients than in the controls. A positive correlation was found between P300 latency and MFIS/MFISmod results, independent from age and MS-related variables. The fatigued patients scored less than non-fatigued ones in tests evaluating memory, visuomotor abilities and attention. Results of these tests correlated significantly with fatigue measures, independently from MS-related variables. Fatigue in MS patients showed significant relationships with impairment within the memory and attention domains. Parameters of auditory ERP, as electrophysiological biomarkers of cognitive performance, were not independently linked to fatigue.
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spelling pubmed-49925032016-09-06 Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue Pokryszko-Dragan, Anna Zagrajek, Mieszko Slotwinski, Krzysztof Bilinska, Malgorzata Gruszka, Ewa Podemski, Ryszard Neurol Sci Original Article The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the Modified Fatigue Impact Scale (MFIS/MFISmod). N200 and P300 components of auditory ERP were analyzed. Cognition was evaluated by means of Brief Repeatable Battery of Neuropsychological Tests (BRBNT). The results of ERP and BRBNT were compared between non-fatigued, moderately and severely fatigued MS patients and controls. P300 latency was significantly longer in the whole MS group and in the fatigued patients than in the controls. A positive correlation was found between P300 latency and MFIS/MFISmod results, independent from age and MS-related variables. The fatigued patients scored less than non-fatigued ones in tests evaluating memory, visuomotor abilities and attention. Results of these tests correlated significantly with fatigue measures, independently from MS-related variables. Fatigue in MS patients showed significant relationships with impairment within the memory and attention domains. Parameters of auditory ERP, as electrophysiological biomarkers of cognitive performance, were not independently linked to fatigue. Springer Milan 2016-06-06 2016 /pmc/articles/PMC4992503/ /pubmed/27271940 http://dx.doi.org/10.1007/s10072-016-2622-x Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Pokryszko-Dragan, Anna
Zagrajek, Mieszko
Slotwinski, Krzysztof
Bilinska, Malgorzata
Gruszka, Ewa
Podemski, Ryszard
Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title_full Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title_fullStr Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title_full_unstemmed Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title_short Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
title_sort event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992503/
https://www.ncbi.nlm.nih.gov/pubmed/27271940
http://dx.doi.org/10.1007/s10072-016-2622-x
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