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Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy

Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent b...

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Autores principales: Yang, Dae Sik, Lee, Jung Ae, Yoon, Won Sup, Lee, Nam Kwon, Park, Young Je, Lee, Suk, Kim, Chul Yong, Son, Gil Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992519/
https://www.ncbi.nlm.nih.gov/pubmed/27579310
http://dx.doi.org/10.1155/2016/3656574
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author Yang, Dae Sik
Lee, Jung Ae
Yoon, Won Sup
Lee, Nam Kwon
Park, Young Je
Lee, Suk
Kim, Chul Yong
Son, Gil Soo
author_facet Yang, Dae Sik
Lee, Jung Ae
Yoon, Won Sup
Lee, Nam Kwon
Park, Young Je
Lee, Suk
Kim, Chul Yong
Son, Gil Soo
author_sort Yang, Dae Sik
collection PubMed
description Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records. For each area of axilla and inferior fold, the intensity score of erythema (score 1 to 5) and extent (score 0 to 1) were summed. The relationship of various parameters to skin reaction was evaluated using chi-square and linear regression tests. The V (100) (volume receiving 100% of prescribed radiation dose, p < 0.001, both axilla and inferior fold) and age (p = 0.039 for axilla and 0.026 for inferior fold) were significant parameters in multivariate analyses. The calculated axilla dose (p = 0.003) and breast separation (p = 0.036) were also risk factors for axilla and inferior fold, respectively. Young age and large V (100) are significant factors for acute skin reaction that can be simply and cost-effectively measured.
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spelling pubmed-49925192016-08-30 Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy Yang, Dae Sik Lee, Jung Ae Yoon, Won Sup Lee, Nam Kwon Park, Young Je Lee, Suk Kim, Chul Yong Son, Gil Soo Biomed Res Int Clinical Study Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records. For each area of axilla and inferior fold, the intensity score of erythema (score 1 to 5) and extent (score 0 to 1) were summed. The relationship of various parameters to skin reaction was evaluated using chi-square and linear regression tests. The V (100) (volume receiving 100% of prescribed radiation dose, p < 0.001, both axilla and inferior fold) and age (p = 0.039 for axilla and 0.026 for inferior fold) were significant parameters in multivariate analyses. The calculated axilla dose (p = 0.003) and breast separation (p = 0.036) were also risk factors for axilla and inferior fold, respectively. Young age and large V (100) are significant factors for acute skin reaction that can be simply and cost-effectively measured. Hindawi Publishing Corporation 2016 2016-08-07 /pmc/articles/PMC4992519/ /pubmed/27579310 http://dx.doi.org/10.1155/2016/3656574 Text en Copyright © 2016 Dae Sik Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Yang, Dae Sik
Lee, Jung Ae
Yoon, Won Sup
Lee, Nam Kwon
Park, Young Je
Lee, Suk
Kim, Chul Yong
Son, Gil Soo
Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title_full Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title_fullStr Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title_full_unstemmed Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title_short Comprehensive Evaluation of Personal, Clinical, and Radiation Dosimetric Parameters for Acute Skin Reaction during Whole Breast Radiotherapy
title_sort comprehensive evaluation of personal, clinical, and radiation dosimetric parameters for acute skin reaction during whole breast radiotherapy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992519/
https://www.ncbi.nlm.nih.gov/pubmed/27579310
http://dx.doi.org/10.1155/2016/3656574
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