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Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome

Introduction. Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the ph...

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Autores principales: Acelajado, Maria Czarina, Culpepper, R. Michael, Bolton III, Wilburn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992520/
https://www.ncbi.nlm.nih.gov/pubmed/27579038
http://dx.doi.org/10.1155/2016/2407607
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author Acelajado, Maria Czarina
Culpepper, R. Michael
Bolton III, Wilburn D.
author_facet Acelajado, Maria Czarina
Culpepper, R. Michael
Bolton III, Wilburn D.
author_sort Acelajado, Maria Czarina
collection PubMed
description Introduction. Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the physiologic range by increased levels of progesterone, which resist kaliuresis. In the presence of GS, this compensatory mechanism is easily overwhelmed, resulting in profound hypokalemia. We present a case of an 18-year-old primigravida with undiagnosed GS who presented with hyperemesis gravidarum in her 7th week of pregnancy. This report adds to the limited experience with GS in pregnancy as reported in literature and provides additional information on medical management that leads to successful maternal and fetal outcomes.
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spelling pubmed-49925202016-08-30 Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome Acelajado, Maria Czarina Culpepper, R. Michael Bolton III, Wilburn D. Case Rep Med Case Report Introduction. Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the physiologic range by increased levels of progesterone, which resist kaliuresis. In the presence of GS, this compensatory mechanism is easily overwhelmed, resulting in profound hypokalemia. We present a case of an 18-year-old primigravida with undiagnosed GS who presented with hyperemesis gravidarum in her 7th week of pregnancy. This report adds to the limited experience with GS in pregnancy as reported in literature and provides additional information on medical management that leads to successful maternal and fetal outcomes. Hindawi Publishing Corporation 2016 2016-08-07 /pmc/articles/PMC4992520/ /pubmed/27579038 http://dx.doi.org/10.1155/2016/2407607 Text en Copyright © 2016 Maria Czarina Acelajado et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Acelajado, Maria Czarina
Culpepper, R. Michael
Bolton III, Wilburn D.
Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title_full Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title_fullStr Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title_full_unstemmed Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title_short Hyperemesis Gravidarum in Undiagnosed Gitelman's Syndrome
title_sort hyperemesis gravidarum in undiagnosed gitelman's syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992520/
https://www.ncbi.nlm.nih.gov/pubmed/27579038
http://dx.doi.org/10.1155/2016/2407607
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