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Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Spec...

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Detalles Bibliográficos
Autores principales: Bandera Merchan, Borja, Tinahones, Francisco José, Macías-González, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992792/
https://www.ncbi.nlm.nih.gov/pubmed/27579030
http://dx.doi.org/10.1155/2016/2308249
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author Bandera Merchan, Borja
Tinahones, Francisco José
Macías-González, Manuel
author_facet Bandera Merchan, Borja
Tinahones, Francisco José
Macías-González, Manuel
author_sort Bandera Merchan, Borja
collection PubMed
description The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.
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spelling pubmed-49927922016-08-30 Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis Bandera Merchan, Borja Tinahones, Francisco José Macías-González, Manuel PPAR Res Review Article The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research. Hindawi Publishing Corporation 2016 2016-08-08 /pmc/articles/PMC4992792/ /pubmed/27579030 http://dx.doi.org/10.1155/2016/2308249 Text en Copyright © 2016 Borja Bandera Merchan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bandera Merchan, Borja
Tinahones, Francisco José
Macías-González, Manuel
Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title_full Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title_fullStr Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title_full_unstemmed Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title_short Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
title_sort commonalities in the association between pparg and vitamin d related with obesity and carcinogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992792/
https://www.ncbi.nlm.nih.gov/pubmed/27579030
http://dx.doi.org/10.1155/2016/2308249
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