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Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Spec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992792/ https://www.ncbi.nlm.nih.gov/pubmed/27579030 http://dx.doi.org/10.1155/2016/2308249 |
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author | Bandera Merchan, Borja Tinahones, Francisco José Macías-González, Manuel |
author_facet | Bandera Merchan, Borja Tinahones, Francisco José Macías-González, Manuel |
author_sort | Bandera Merchan, Borja |
collection | PubMed |
description | The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research. |
format | Online Article Text |
id | pubmed-4992792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49927922016-08-30 Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis Bandera Merchan, Borja Tinahones, Francisco José Macías-González, Manuel PPAR Res Review Article The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research. Hindawi Publishing Corporation 2016 2016-08-08 /pmc/articles/PMC4992792/ /pubmed/27579030 http://dx.doi.org/10.1155/2016/2308249 Text en Copyright © 2016 Borja Bandera Merchan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bandera Merchan, Borja Tinahones, Francisco José Macías-González, Manuel Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title | Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title_full | Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title_fullStr | Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title_full_unstemmed | Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title_short | Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis |
title_sort | commonalities in the association between pparg and vitamin d related with obesity and carcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992792/ https://www.ncbi.nlm.nih.gov/pubmed/27579030 http://dx.doi.org/10.1155/2016/2308249 |
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