Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy

Bispecific antibodies are of great interest due to their ability to simultaneously bind and engage different antigens or epitopes. Nevertheless, it remains a challenge to assemble, produce and/or purify them. Here we present an innovative dual anti-idiotypic purification process, which provides pure...

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Detalles Bibliográficos
Autores principales: Godar, Marie, Morello, Virginia, Sadi, Ava, Hultberg, Anna, De Jonge, Natalie, Basilico, Cristina, Hanssens, Valérie, Saunders, Michael, Lambrecht, Bart N., El Khattabi, Mohamed, de Haard, Hans, Michieli, Paolo, Blanchetot, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992859/
https://www.ncbi.nlm.nih.gov/pubmed/27546726
http://dx.doi.org/10.1038/srep31621

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