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Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study
Evidence on the clinical effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for time trend and feeding type. This study investigated the association between the introduction of routine probiotics (La...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992873/ https://www.ncbi.nlm.nih.gov/pubmed/27545195 http://dx.doi.org/10.1038/srep31643 |
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author | Samuels, Noor van de Graaf, Rob Been, Jasper V. de Jonge, Rogier C. J. Hanff, Lidwien M. Wijnen, René M. H. Kornelisse, René F. Reiss, Irwin K. M. Vermeulen, Marijn J. |
author_facet | Samuels, Noor van de Graaf, Rob Been, Jasper V. de Jonge, Rogier C. J. Hanff, Lidwien M. Wijnen, René M. H. Kornelisse, René F. Reiss, Irwin K. M. Vermeulen, Marijn J. |
author_sort | Samuels, Noor |
collection | PubMed |
description | Evidence on the clinical effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for time trend and feeding type. This study investigated the association between the introduction of routine probiotics (Lactobacillus acidophilus and Bifidobacterium bifidum; Infloran(®)) on the primary outcome ‘NEC or death’. Preterm infants (gestational age <32 weeks or birth weight <1500 gram) admitted before (Jan 2008–Sep 2012; n = 1288) and after (Oct 2012–Dec 2014; n = 673) introduction of probiotics were compared. Interrupted time series logistic regression models were adjusted for confounders, effect modification by feeding type, seasonality and underlying temporal trends. Unadjusted and adjusted analyses showed no difference in ‘NEC or death’ between the two periods. The overall incidence of NEC declined from 7.8% to 5.1% (OR 0.63, 95% CI 0.42–0.93, p = 0.02), which was not statistically significant in the adjusted models. Introduction of probiotics was associated with a reduced adjusted odds for ‘NEC or sepsis or death’ in exclusively breastmilk-fed infants (OR 0.43, 95% CI 0.21–0.93, p = 0.03) only. We conclude that introduction of probiotics was not associated with a reduction in ‘NEC or death’ and that type of feeding seems to modify the effects of probiotics. |
format | Online Article Text |
id | pubmed-4992873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49928732016-08-30 Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study Samuels, Noor van de Graaf, Rob Been, Jasper V. de Jonge, Rogier C. J. Hanff, Lidwien M. Wijnen, René M. H. Kornelisse, René F. Reiss, Irwin K. M. Vermeulen, Marijn J. Sci Rep Article Evidence on the clinical effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for time trend and feeding type. This study investigated the association between the introduction of routine probiotics (Lactobacillus acidophilus and Bifidobacterium bifidum; Infloran(®)) on the primary outcome ‘NEC or death’. Preterm infants (gestational age <32 weeks or birth weight <1500 gram) admitted before (Jan 2008–Sep 2012; n = 1288) and after (Oct 2012–Dec 2014; n = 673) introduction of probiotics were compared. Interrupted time series logistic regression models were adjusted for confounders, effect modification by feeding type, seasonality and underlying temporal trends. Unadjusted and adjusted analyses showed no difference in ‘NEC or death’ between the two periods. The overall incidence of NEC declined from 7.8% to 5.1% (OR 0.63, 95% CI 0.42–0.93, p = 0.02), which was not statistically significant in the adjusted models. Introduction of probiotics was associated with a reduced adjusted odds for ‘NEC or sepsis or death’ in exclusively breastmilk-fed infants (OR 0.43, 95% CI 0.21–0.93, p = 0.03) only. We conclude that introduction of probiotics was not associated with a reduction in ‘NEC or death’ and that type of feeding seems to modify the effects of probiotics. Nature Publishing Group 2016-08-22 /pmc/articles/PMC4992873/ /pubmed/27545195 http://dx.doi.org/10.1038/srep31643 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Samuels, Noor van de Graaf, Rob Been, Jasper V. de Jonge, Rogier C. J. Hanff, Lidwien M. Wijnen, René M. H. Kornelisse, René F. Reiss, Irwin K. M. Vermeulen, Marijn J. Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title | Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title_full | Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title_fullStr | Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title_full_unstemmed | Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title_short | Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
title_sort | necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992873/ https://www.ncbi.nlm.nih.gov/pubmed/27545195 http://dx.doi.org/10.1038/srep31643 |
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