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Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study
The hormone oxytocin has been hypothesized to influence the emotional dimension of pain. This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. After receiving 36 IU...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992880/ https://www.ncbi.nlm.nih.gov/pubmed/27546446 http://dx.doi.org/10.1038/srep31606 |
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author | Zunhammer, Matthias Geis, Sandra Busch, Volker Eichhammer, Peter Greenlee, Mark W. |
author_facet | Zunhammer, Matthias Geis, Sandra Busch, Volker Eichhammer, Peter Greenlee, Mark W. |
author_sort | Zunhammer, Matthias |
collection | PubMed |
description | The hormone oxytocin has been hypothesized to influence the emotional dimension of pain. This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. After receiving 36 IU oxytocin or placebo, participants underwent functional Magnetic Resonance Imaging (fMRI) during which noxious and non-noxious thermode heat stimuli were applied. Simultaneously, scenes from the International Affective Pictures System (IAPS) with positive, neutral, and negative emotional valence were shown. Heat intensity and unpleasantness ratings were obtained. The activity of whole-brain correlates of heat processing was quantified via multi-voxel pattern analysis. We observed no appreciable main effects of oxytocin on ratings or neural pain correlates. Effects of emotional picture valence on ratings were smaller than reported in previous studies. Nevertheless, oxytocin was found to significantly enhance the influence of picture valence on unpleasantness ratings at noxious heat levels. No corresponding changes in whole-brain correlates of heat intensity processing were found. Our study provides evidence that intranasal oxytocin increases the effects of emotional context on the subjective unpleasantness of experimental heat pain. Future studies are needed to determine whether this effect can be utilized in clinical settings. |
format | Online Article Text |
id | pubmed-4992880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49928802016-08-30 Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study Zunhammer, Matthias Geis, Sandra Busch, Volker Eichhammer, Peter Greenlee, Mark W. Sci Rep Article The hormone oxytocin has been hypothesized to influence the emotional dimension of pain. This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. After receiving 36 IU oxytocin or placebo, participants underwent functional Magnetic Resonance Imaging (fMRI) during which noxious and non-noxious thermode heat stimuli were applied. Simultaneously, scenes from the International Affective Pictures System (IAPS) with positive, neutral, and negative emotional valence were shown. Heat intensity and unpleasantness ratings were obtained. The activity of whole-brain correlates of heat processing was quantified via multi-voxel pattern analysis. We observed no appreciable main effects of oxytocin on ratings or neural pain correlates. Effects of emotional picture valence on ratings were smaller than reported in previous studies. Nevertheless, oxytocin was found to significantly enhance the influence of picture valence on unpleasantness ratings at noxious heat levels. No corresponding changes in whole-brain correlates of heat intensity processing were found. Our study provides evidence that intranasal oxytocin increases the effects of emotional context on the subjective unpleasantness of experimental heat pain. Future studies are needed to determine whether this effect can be utilized in clinical settings. Nature Publishing Group 2016-08-22 /pmc/articles/PMC4992880/ /pubmed/27546446 http://dx.doi.org/10.1038/srep31606 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zunhammer, Matthias Geis, Sandra Busch, Volker Eichhammer, Peter Greenlee, Mark W. Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title | Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title_full | Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title_fullStr | Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title_full_unstemmed | Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title_short | Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study |
title_sort | pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fmri study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992880/ https://www.ncbi.nlm.nih.gov/pubmed/27546446 http://dx.doi.org/10.1038/srep31606 |
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