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Increasing the performance of pooled CRISPR–Cas9 drop-out screening

Components of the type II CRISPR–Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing new opportunities for drug target identification an...

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Detalles Bibliográficos
Autores principales:	Cross, Benedict C. S., Lawo, Steffen, Archer, Caroline R., Hunt, Jessica R., Yarker, Joanne L., Riccombeni, Alessandro, Little, Annette S., McCarthy, Nicola J., Moore, Jonathan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992892/ https://www.ncbi.nlm.nih.gov/pubmed/27545104 http://dx.doi.org/10.1038/srep31782

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