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Drug induced exfoliative dermatitis: state of the art

Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the mai...

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Detalles Bibliográficos
Autores principales: Yacoub, Mona-Rita, Berti, Alvise, Campochiaro, Corrado, Tombetti, Enrico, Ramirez, Giuseppe Alvise, Nico, Andrea, Di Leo, Elisabetta, Fantini, Paola, Sabbadini, Maria Grazia, Nettis, Eustachio, Colombo, Giselda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993006/
https://www.ncbi.nlm.nih.gov/pubmed/27551239
http://dx.doi.org/10.1186/s12948-016-0045-0
Descripción
Sumario:Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12948-016-0045-0) contains supplementary material, which is available to authorized users.