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Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and Its Alteration During Ischemia and Reperfusion
Oxidation of substrates to generate ATP in mitochondria is mediated by redox reactions of NADH and FADH(2). Cardiac ischemia and reperfusion (IR) injury compromises mitochondrial oxidative phosphorylation. We hypothesize that IR alters the metabolic heterogeneity of mitochondrial redox state of the...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
IEEE
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993131/ https://www.ncbi.nlm.nih.gov/pubmed/27574574 http://dx.doi.org/10.1109/JTEHM.2016.2570219 |