Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and gastrointestinal toxicity. We synthesized PTX nanomicelles using poly(styrene-co-maleic acid) (SMA). Oral administration of...

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Detalles Bibliográficos
Autores principales: Parayath, Neha N, Nehoff, Hayley, Norton, Samuel E, Highton, Andrew J, Taurin, Sebastien, Kemp, Roslyn A, Greish, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993259/
https://www.ncbi.nlm.nih.gov/pubmed/27574427
http://dx.doi.org/10.2147/IJN.S110251

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