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Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey

PURPOSE: To demonstrate the clinical characteristics and treatment outcomes of severe retinopathy of prematurity (ROP) in preterm infants with birth weight (BW) above 1500 g in Turkey. METHODS: A retrospective review of 5920 ROP records was performed in Zeynep Kamil Maternity and Children’s Diseases...

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Detalles Bibliográficos
Autores principales: Gunay, Murat, Celik, Gokhan, Tuten, Abdulhamit, Karatekin, Guner, Bardak, Handan, Ovali, Fahri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993354/
https://www.ncbi.nlm.nih.gov/pubmed/27548628
http://dx.doi.org/10.1371/journal.pone.0161692
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author Gunay, Murat
Celik, Gokhan
Tuten, Abdulhamit
Karatekin, Guner
Bardak, Handan
Ovali, Fahri
author_facet Gunay, Murat
Celik, Gokhan
Tuten, Abdulhamit
Karatekin, Guner
Bardak, Handan
Ovali, Fahri
author_sort Gunay, Murat
collection PubMed
description PURPOSE: To demonstrate the clinical characteristics and treatment outcomes of severe retinopathy of prematurity (ROP) in preterm infants with birth weight (BW) above 1500 g in Turkey. METHODS: A retrospective review of 5920 ROP records was performed in Zeynep Kamil Maternity and Children’s Diseases Training and Research Hospital. The records were obtained from ROP treatment center of the same institute between 2011 and 2016. The data comprised the demographic and clinical characteristics including, gestational age, BW, systemic risk factors, zone and stage of ROP, ROP type, treatment modality, treatment outcomes and inborn/outborn status of the babies. RESULTS: A total of 36 infants (71 eyes) with severe ROP and BW> 1500 g were retrieved. There were 30 infants (83.3%) with type 1 ROP and 6 infants (16.7%) with aggressive posterior ROP (APROP). 3 infants (8.3%) were born at our hospital whereas 33 (91.7%) were referred from outer private neonatal intensive care unit (NICU) centers. Zone I APROP was detected during the initial screening. 21 infants (58.3%) underwent laser treatment while 15 (41.7%) received intravitreal bevacizumab (IVB) injections. No unfavorable structural outcome was observed following either treatment modality. CONCLUSION: Severe ROP may occur in heavier preterm infants. Laser treatment and IVB injections were useful in selected cases. Presence of APROP at first examination suggests an earlier screening in heavier babies. Standardization of private NICU centers as well as establishing a national ROP protocol is necessary in Turkey.
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spelling pubmed-49933542016-09-12 Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey Gunay, Murat Celik, Gokhan Tuten, Abdulhamit Karatekin, Guner Bardak, Handan Ovali, Fahri PLoS One Research Article PURPOSE: To demonstrate the clinical characteristics and treatment outcomes of severe retinopathy of prematurity (ROP) in preterm infants with birth weight (BW) above 1500 g in Turkey. METHODS: A retrospective review of 5920 ROP records was performed in Zeynep Kamil Maternity and Children’s Diseases Training and Research Hospital. The records were obtained from ROP treatment center of the same institute between 2011 and 2016. The data comprised the demographic and clinical characteristics including, gestational age, BW, systemic risk factors, zone and stage of ROP, ROP type, treatment modality, treatment outcomes and inborn/outborn status of the babies. RESULTS: A total of 36 infants (71 eyes) with severe ROP and BW> 1500 g were retrieved. There were 30 infants (83.3%) with type 1 ROP and 6 infants (16.7%) with aggressive posterior ROP (APROP). 3 infants (8.3%) were born at our hospital whereas 33 (91.7%) were referred from outer private neonatal intensive care unit (NICU) centers. Zone I APROP was detected during the initial screening. 21 infants (58.3%) underwent laser treatment while 15 (41.7%) received intravitreal bevacizumab (IVB) injections. No unfavorable structural outcome was observed following either treatment modality. CONCLUSION: Severe ROP may occur in heavier preterm infants. Laser treatment and IVB injections were useful in selected cases. Presence of APROP at first examination suggests an earlier screening in heavier babies. Standardization of private NICU centers as well as establishing a national ROP protocol is necessary in Turkey. Public Library of Science 2016-08-22 /pmc/articles/PMC4993354/ /pubmed/27548628 http://dx.doi.org/10.1371/journal.pone.0161692 Text en © 2016 Gunay et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gunay, Murat
Celik, Gokhan
Tuten, Abdulhamit
Karatekin, Guner
Bardak, Handan
Ovali, Fahri
Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title_full Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title_fullStr Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title_full_unstemmed Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title_short Characteristics of Severe Retinopathy of Prematurity in Infants with Birth Weight above 1500 Grams at a Referral Center in Turkey
title_sort characteristics of severe retinopathy of prematurity in infants with birth weight above 1500 grams at a referral center in turkey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993354/
https://www.ncbi.nlm.nih.gov/pubmed/27548628
http://dx.doi.org/10.1371/journal.pone.0161692
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