Vaccine-Mediated Activation of Human TLR4 Is Affected by Modulation of Culture Conditions during Whole-Cell Pertussis Vaccine Preparation

The potency of whole-cell pertussis (wP) vaccines is still determined by an intracerebral mouse protection test. To allow development of suitable in vitro alternatives to this test, insight into relevant parameters to monitor the consistency of vaccine quality is essential. To this end, a panel of e...

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Detalles Bibliográficos
Autores principales: Hoonakker, Marieke E., Verhagen, Lisa M., Pupo, Elder, de Haan, Alex, Metz, Bernard, Hendriksen, Coenraad F. M., Han, Wanda G. H., Sloots, Arjen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993483/
https://www.ncbi.nlm.nih.gov/pubmed/27548265
http://dx.doi.org/10.1371/journal.pone.0161428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993483/
https://www.ncbi.nlm.nih.gov/pubmed/27548265
http://dx.doi.org/10.1371/journal.pone.0161428

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