Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of V(L) and V(H) Domains Targeting CD123(+) Tumors

Adoptive immunotherapy infusing T cells with engineered specificity for CD19 expressed on B- cell malignancies is generating enthusiasm to extend this approach to other hematological malignancies, such as acute myelogenous leukemia (AML). CD123, or interleukin 3 receptor alpha, is overexpressed on m...

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Detalles Bibliográficos
Autores principales: Thokala, Radhika, Olivares, Simon, Mi, Tiejuan, Maiti, Sourindra, Deniger, Drew, Huls, Helen, Torikai, Hiroki, Singh, Harjeet, Champlin, Richard E., Laskowski, Tamara, McNamara, George, Cooper, Laurence J. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993583/
https://www.ncbi.nlm.nih.gov/pubmed/27548616
http://dx.doi.org/10.1371/journal.pone.0159477

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