Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Cerebral small vessel disease (SVD) is a leading cause of stroke and dementia. CADASIL, an inherited SVD, alters cerebral artery function, compromising blood flow to the working brain. TIMP3 (tissue inhibitor of metalloproteinase 3) accumulation in the vascular extracellular matrix in CADASIL is a k...

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Detalles Bibliográficos
Autores principales: Capone, Carmen, Dabertrand, Fabrice, Baron-Menguy, Celine, Chalaris, Athena, Ghezali, Lamia, Domenga-Denier, Valérie, Schmidt, Stefanie, Huneau, Clément, Rose-John, Stefan, Nelson, Mark T, Joutel, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993587/
https://www.ncbi.nlm.nih.gov/pubmed/27476853
http://dx.doi.org/10.7554/eLife.17536

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