Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte

Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery d...

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Autores principales: Porta-i-Batalla, Maria, Eckstein, Chris, Xifré-Pérez, Elisabet, Formentín, Pilar, Ferré-Borrull, J., Marsal, Lluis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993726/
https://www.ncbi.nlm.nih.gov/pubmed/27550052
http://dx.doi.org/10.1186/s11671-016-1585-4
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author Porta-i-Batalla, Maria
Eckstein, Chris
Xifré-Pérez, Elisabet
Formentín, Pilar
Ferré-Borrull, J.
Marsal, Lluis F.
author_facet Porta-i-Batalla, Maria
Eckstein, Chris
Xifré-Pérez, Elisabet
Formentín, Pilar
Ferré-Borrull, J.
Marsal, Lluis F.
author_sort Porta-i-Batalla, Maria
collection PubMed
description Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery due to its biocompatibility, stability, and controllable pore geometry. Its use in drug delivery applications has been explored in several fields, including therapeutic devices for bone and dental tissue engineering, coronary stent implants, and carriers for transplanted cells. In this work, we have created and analyzed a stimuli-responsive drug delivery system based on layer-by-layer pH-responsive polyelectrolyte and nanoporous anodic alumina. The results demonstrate that it is possible to control the drug release using a polyelectrolyte multilayer coating that will act as a gate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-016-1585-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-49937262016-09-08 Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte Porta-i-Batalla, Maria Eckstein, Chris Xifré-Pérez, Elisabet Formentín, Pilar Ferré-Borrull, J. Marsal, Lluis F. Nanoscale Res Lett Nano Express Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery due to its biocompatibility, stability, and controllable pore geometry. Its use in drug delivery applications has been explored in several fields, including therapeutic devices for bone and dental tissue engineering, coronary stent implants, and carriers for transplanted cells. In this work, we have created and analyzed a stimuli-responsive drug delivery system based on layer-by-layer pH-responsive polyelectrolyte and nanoporous anodic alumina. The results demonstrate that it is possible to control the drug release using a polyelectrolyte multilayer coating that will act as a gate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-016-1585-4) contains supplementary material, which is available to authorized users. Springer US 2016-08-23 /pmc/articles/PMC4993726/ /pubmed/27550052 http://dx.doi.org/10.1186/s11671-016-1585-4 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Porta-i-Batalla, Maria
Eckstein, Chris
Xifré-Pérez, Elisabet
Formentín, Pilar
Ferré-Borrull, J.
Marsal, Lluis F.
Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title_full Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title_fullStr Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title_full_unstemmed Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title_short Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte
title_sort sustained, controlled and stimuli-responsive drug release systems based on nanoporous anodic alumina with layer-by-layer polyelectrolyte
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993726/
https://www.ncbi.nlm.nih.gov/pubmed/27550052
http://dx.doi.org/10.1186/s11671-016-1585-4
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