Cargando…

Elevated Hapln2 Expression Contributes to Protein Aggregation and Neurodegeneration in an Animal Model of Parkinson's Disease

Parkinson's disease (PD), the second most common age-associated progressive neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SN). The pathogenesis of PD and the mechanisms underlying the degeneration of DA neurons are s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qinqin, Zhou, Qinbo, Zhang, Shuzhen, Shao, Wei, Yin, Yanqing, Li, Yandong, Hou, Jincan, Zhang, Xinhua, Guo, Yongshun, Wang, Xiaomin, Gu, Xiaosong, Zhou, Jiawei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993759/ https://www.ncbi.nlm.nih.gov/pubmed/27601993 http://dx.doi.org/10.3389/fnagi.2016.00197

Ejemplares similares

Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target
por: Wang, Qinqin, et al.
Publicado: (2019)

HAPLN1 potentiates peritoneal metastasis in pancreatic cancer
por: Wiedmann, Lena, et al.
Publicado: (2023)

hapln1a(+) cells guide coronary growth during heart morphogenesis and regeneration
por: Sun, Jisheng, et al.
Publicado: (2023)

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
por: Chen, Yong, et al.
Publicado: (2020)

HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes
por: Chen, Yong, et al.
Publicado: (2022)

HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs
por: Huynh, Mailee, et al.
Publicado: (2022)

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
por: Wang, Qinqin, et al.
Publicado: (2015)

Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer
por: Zhang, Tiancheng, et al.
Publicado: (2021)

Hapln1a Is Required for Connexin43-Dependent Growth and Patterning in the Regenerating Fin Skeleton
por: Govindan, Jayalakshmi, et al.
Publicado: (2014)

Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma
por: De Bakshi, Debayan, et al.
Publicado: (2022)

Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth
por: Ha, Hae Chan, et al.
Publicado: (2023)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

ASPN Synergizes with HAPLN1 to Inhibit the Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells and Extracellular Matrix Mineralization of Osteoblasts
por: Zhou, Guohui, et al.
Publicado: (2023)

A Novel Role of Hyaluronic Acid and Proteoglycan Link Protein 1 (HAPLN1) in Delaying Vascular Endothelial Cell Senescence
por: Zhou, Dan, et al.
Publicado: (2023)

Transcriptome Analysis Reveals MFGE8-HAPLN3 Fusion as a Novel Biomarker in Triple-Negative Breast Cancer
por: Wang, Meng-Yuan, et al.
Publicado: (2021)

HAPLN1 matrikine: a bone marrow homing factor linked to poor outcomes in patients with MM
por: Chang, Hae Yeun, et al.
Publicado: (2023)

Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin–Beck disease and primary osteoarthritis
por: Zheng, Jingjing, et al.
Publicado: (2013)

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease
por: Romaní-Aumedes, J, et al.
Publicado: (2014)

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development
por: Derrick, Christopher J, et al.
Publicado: (2021)

Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish
por: Mahony, Christopher B., et al.
Publicado: (2021)

Aggregation of Disordered Proteins Associated with Neurodegeneration
por: Tsoi, Phoebe S., et al.
Publicado: (2023)

Nigral Iron Elevation Is an Invariable Feature of Parkinson's Disease and Is a Sufficient Cause of Neurodegeneration
por: Ayton, Scott, et al.
Publicado: (2014)

Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease
por: Zhou, Cheng, et al.
Publicado: (2023)

Neurodegeneration and neuroprotection in Parkinson's disease /
Publicado: (1996)

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020)

Prion-like spread of protein aggregates in neurodegeneration
por: Polymenidou, Magdalini, et al.
Publicado: (2012)

Regulated protein aggregation: stress granules and neurodegeneration
por: Wolozin, Benjamin
Publicado: (2012)

RNA-binding proteins in neurodegeneration: mechanisms in aggregate
por: Conlon, Erin G., et al.
Publicado: (2017)

Exceptional in vivo catabolism of neurodegeneration-related aggregates
por: Datki, Zsolt, et al.
Publicado: (2018)

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
por: Zeng, Xian-Si, et al.
Publicado: (2018)

Association of p53 with Neurodegeneration in Parkinson's Disease
por: Luo, Qiang, et al.
Publicado: (2022)

Aggregation of TDP-43 fragments triggers cellular aberrant function: implication in neurodegeneration
por: Che, Meixia, et al.
Publicado: (2012)

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas
por: Mebarki, Sihem, et al.
Publicado: (2016)

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson’s disease, causes behavioral alterations but not neurodegeneration in mice
por: Ageta-Ishihara, Natsumi, et al.
Publicado: (2013)

Cyclooxygenase and Neuroinflammation in Parkinson’s Disease Neurodegeneration
por: Bartels, Anna L, et al.
Publicado: (2010)

Parkinson’s disease managing reversible neurodegeneration
por: Hinz, Marty, et al.
Publicado: (2016)

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease
por: Gelders, Géraldine, et al.
Publicado: (2018)

Nucleo–cytoplasmic transport defects and protein aggregates in neurodegeneration
por: Bitetto, Giacomo, et al.
Publicado: (2020)

Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration
por: Govindan, Jayalakshmi, et al.
Publicado: (2016)

Recombinant Human HAPLN1 Mitigates Pulmonary Emphysema by Increasing TGF-β Receptor I and Sirtuins Levels in Human Alveolar Epithelial Cells
por: Piao, Yongwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_652rmmqs7qju23naphmte6mfrh