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Hypotensive Resuscitation among Trauma Patients

Hemorrhagic shock is a principal cause of death among trauma patients within the first 24 hours after injury. Optimal fluid resuscitation strategies have been examined for nearly a century, more recently with several randomized controlled trials. Hypotensive resuscitation, also called permissive hyp...

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Autores principales: Carrick, Matthew M., Leonard, Jan, Slone, Denetta S., Mains, Charles W., Bar-Or, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993927/
https://www.ncbi.nlm.nih.gov/pubmed/27595109
http://dx.doi.org/10.1155/2016/8901938
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author Carrick, Matthew M.
Leonard, Jan
Slone, Denetta S.
Mains, Charles W.
Bar-Or, David
author_facet Carrick, Matthew M.
Leonard, Jan
Slone, Denetta S.
Mains, Charles W.
Bar-Or, David
author_sort Carrick, Matthew M.
collection PubMed
description Hemorrhagic shock is a principal cause of death among trauma patients within the first 24 hours after injury. Optimal fluid resuscitation strategies have been examined for nearly a century, more recently with several randomized controlled trials. Hypotensive resuscitation, also called permissive hypotension, is a resuscitation strategy that uses limited fluids and blood products during the early stages of treatment for hemorrhagic shock. A lower-than-normal blood pressure is maintained until operative control of the bleeding can occur. The randomized controlled trials examining restricted fluid resuscitation have demonstrated that aggressive fluid resuscitation in the prehospital and hospital setting leads to more complications than hypotensive resuscitation, with disparate findings on the survival benefit. Since the populations studied in each randomized controlled trial are slightly different, as is the timing of intervention and targeted vitals, there is still a need for a large, multicenter trial that can examine the benefit of hypotensive resuscitation in both blunt and penetrating trauma patients.
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spelling pubmed-49939272016-09-04 Hypotensive Resuscitation among Trauma Patients Carrick, Matthew M. Leonard, Jan Slone, Denetta S. Mains, Charles W. Bar-Or, David Biomed Res Int Review Article Hemorrhagic shock is a principal cause of death among trauma patients within the first 24 hours after injury. Optimal fluid resuscitation strategies have been examined for nearly a century, more recently with several randomized controlled trials. Hypotensive resuscitation, also called permissive hypotension, is a resuscitation strategy that uses limited fluids and blood products during the early stages of treatment for hemorrhagic shock. A lower-than-normal blood pressure is maintained until operative control of the bleeding can occur. The randomized controlled trials examining restricted fluid resuscitation have demonstrated that aggressive fluid resuscitation in the prehospital and hospital setting leads to more complications than hypotensive resuscitation, with disparate findings on the survival benefit. Since the populations studied in each randomized controlled trial are slightly different, as is the timing of intervention and targeted vitals, there is still a need for a large, multicenter trial that can examine the benefit of hypotensive resuscitation in both blunt and penetrating trauma patients. Hindawi Publishing Corporation 2016 2016-08-09 /pmc/articles/PMC4993927/ /pubmed/27595109 http://dx.doi.org/10.1155/2016/8901938 Text en Copyright © 2016 Matthew M. Carrick et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Carrick, Matthew M.
Leonard, Jan
Slone, Denetta S.
Mains, Charles W.
Bar-Or, David
Hypotensive Resuscitation among Trauma Patients
title Hypotensive Resuscitation among Trauma Patients
title_full Hypotensive Resuscitation among Trauma Patients
title_fullStr Hypotensive Resuscitation among Trauma Patients
title_full_unstemmed Hypotensive Resuscitation among Trauma Patients
title_short Hypotensive Resuscitation among Trauma Patients
title_sort hypotensive resuscitation among trauma patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993927/
https://www.ncbi.nlm.nih.gov/pubmed/27595109
http://dx.doi.org/10.1155/2016/8901938
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