Cargando…

An Update of Microsomal Prostaglandin E Synthase-1 and PGE(2) Receptors in Cardiovascular Health and Diseases

Nonsteroidal anti-inflammatory drugs (NSAIDs), especially cyclooxygenase-2 (COX-2) selective inhibitors, are among the most widely used drugs to treat pain and inflammation. However, clinical trials have revealed that these inhibitors predisposed patients to a significantly increased cardiovascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Guangrui, Chen, Lihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993943/ https://www.ncbi.nlm.nih.gov/pubmed/27594972 http://dx.doi.org/10.1155/2016/5249086

Ejemplares similares

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
por: Sampey, Annaleise V, et al.
Publicado: (2005)

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases
por: Korotkova, Marina, et al.
Publicado: (2011)

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
por: Zhou, Jiping, et al.
Publicado: (2012)

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE(2) Production in Bone Marrow Derived Macrophages
por: Xiao, Lei, et al.
Publicado: (2012)

Active Smoking Increases Microsomal PGE(2)-Synthase-1/PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms
por: Dilmé, Jaime-Félix, et al.
Publicado: (2014)

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE(2) biosynthesis by sonlicromanol’s metabolite KH176m
por: Jiang, X., et al.
Publicado: (2021)

Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and −186 expression: Novel mechanism of VEGF modulation in prostate cancer
por: Terzuoli, Erika, et al.
Publicado: (2016)

Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
por: Afif, H, et al.
Publicado: (2004)

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1
por: Cao, Long-Long, et al.
Publicado: (2019)

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
por: Gurusamy, Malarvizhi, et al.
Publicado: (2021)

Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Pulmonary Fibrosis Induced by Bleomycin in Mice
por: Wei, Bo, et al.
Publicado: (2014)

Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease
por: Kotsos, Dimitrios, et al.
Publicado: (2023)

Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo
por: Kats, Anna, et al.
Publicado: (2013)

Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
por: Korotkova, M, et al.
Publicado: (2005)

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
por: Korotkova, M, et al.
Publicado: (2004)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
por: Kock, Anna, et al.
Publicado: (2018)

Pharmacological Characterization of the Microsomal Prostaglandin E(2) Synthase-1 Inhibitor AF3485 In Vitro and In Vivo
por: Di Francesco, Luigia, et al.
Publicado: (2020)

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis
por: Finetti, Federica, et al.
Publicado: (2012)

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
por: Kamei, Daisuke, et al.
Publicado: (2009)

Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia
por: Mukai, Manabu, et al.
Publicado: (2018)

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
por: Yasmen, Nelufar, et al.
Publicado: (2023)

Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes
por: Zayed, N, et al.
Publicado: (2010)

Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E(2) synthase up-regulation for colorectal cancer progression
por: Stamatakis, Konstantinos, et al.
Publicado: (2015)

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo
por: Koeberle, Andreas, et al.
Publicado: (2011)

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E(2) Synthase 1 and Ser127 Is Not
por: Raouf, Joan, et al.
Publicado: (2016)

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
por: Korotkova, M, et al.
Publicado: (2008)

Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice
por: Nakanishi, Masako, et al.
Publicado: (2021)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
por: Pierre, Clément, et al.
Publicado: (2018)

Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1
por: Tuure, Lauri, et al.
Publicado: (2017)

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1
por: Sasaki, Yuka, et al.
Publicado: (2015)

Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction
por: Lin, You-Min, et al.
Publicado: (2018)

Mammalian oocytes are targets for prostaglandin E2 (PGE2) action
por: Duffy, Diane M, et al.
Publicado: (2010)

Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF Progression
por: Moshkovitz, Noa, et al.
Publicado: (2023)

Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E(2) Synthase-1
por: Verhoff, Moritz, et al.
Publicado: (2014)

Synergistic Suppression of Early Phase of Adipogenesis by Microsomal PGE Synthase-1 (PTGES1)-Produced PGE(2) and Aldo-Keto Reductase 1B3-Produced PGF(2α)
por: Fujimori, Ko, et al.
Publicado: (2012)

PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase‐1 by a mechanism dependent on MAP kinase phosphatase‐1
por: Tuure, Lauri, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mkup5n5leo921t1nibtp5c7r73