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An update of the classical Bokhman's dualistic model of endometrial cancer

According to the classical dualistic model introduced by Bokhman in 1983, endometrial cancer (EC) is divided into two basic types. The prototypical histological type for type I and type II of EC is endometrioid carcinoma and serous carcinoma, respectively. The traditional classification is based on...

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Detalles Bibliográficos
Autores principales: Wilczyński, Miłosz, Danielska, Justyna, Wilczyński, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993978/
https://www.ncbi.nlm.nih.gov/pubmed/27582678
http://dx.doi.org/10.5114/pm.2016.61186
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author Wilczyński, Miłosz
Danielska, Justyna
Wilczyński, Jacek
author_facet Wilczyński, Miłosz
Danielska, Justyna
Wilczyński, Jacek
author_sort Wilczyński, Miłosz
collection PubMed
description According to the classical dualistic model introduced by Bokhman in 1983, endometrial cancer (EC) is divided into two basic types. The prototypical histological type for type I and type II of EC is endometrioid carcinoma and serous carcinoma, respectively. The traditional classification is based on clinical, endocrine and histopathological features, however, it sometimes does not reflect the full heterogeneity of EC. New molecular evidence, supported by clinical diversity of the cancer, indicates that the classical dualistic model is valid only to some extent. The review updates a mutational diversity of EC, introducing a new molecular classification of the tumour in regard to data presented by The Cancer Genome Atlas Research Network (TGCA).
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spelling pubmed-49939782016-08-31 An update of the classical Bokhman's dualistic model of endometrial cancer Wilczyński, Miłosz Danielska, Justyna Wilczyński, Jacek Prz Menopauzalny Featured Paper According to the classical dualistic model introduced by Bokhman in 1983, endometrial cancer (EC) is divided into two basic types. The prototypical histological type for type I and type II of EC is endometrioid carcinoma and serous carcinoma, respectively. The traditional classification is based on clinical, endocrine and histopathological features, however, it sometimes does not reflect the full heterogeneity of EC. New molecular evidence, supported by clinical diversity of the cancer, indicates that the classical dualistic model is valid only to some extent. The review updates a mutational diversity of EC, introducing a new molecular classification of the tumour in regard to data presented by The Cancer Genome Atlas Research Network (TGCA). Termedia Publishing House 2016-07-22 2016-06 /pmc/articles/PMC4993978/ /pubmed/27582678 http://dx.doi.org/10.5114/pm.2016.61186 Text en Copyright: © 2016 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Featured Paper
Wilczyński, Miłosz
Danielska, Justyna
Wilczyński, Jacek
An update of the classical Bokhman's dualistic model of endometrial cancer
title An update of the classical Bokhman's dualistic model of endometrial cancer
title_full An update of the classical Bokhman's dualistic model of endometrial cancer
title_fullStr An update of the classical Bokhman's dualistic model of endometrial cancer
title_full_unstemmed An update of the classical Bokhman's dualistic model of endometrial cancer
title_short An update of the classical Bokhman's dualistic model of endometrial cancer
title_sort update of the classical bokhman's dualistic model of endometrial cancer
topic Featured Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993978/
https://www.ncbi.nlm.nih.gov/pubmed/27582678
http://dx.doi.org/10.5114/pm.2016.61186
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