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Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix
Benign metastasizing leiomyoma (BML) usually are situated in one organ, most often in lungs. BML patients typically have a history of uterine leiomyoma treated with hysterectomy, myomectomy or subtotal hysterectomy. The aim of the study was to present the case of a 53-year-old woman with triple loca...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993987/ https://www.ncbi.nlm.nih.gov/pubmed/27582687 http://dx.doi.org/10.5114/pm.2016.61195 |
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author | Raś, Renata Książek, Mariusz Barnaś, Edyta Skręt-Magierło, Joanna Kąziołka, Wojciech Fudali, Ludmiła Filipowska, Justyna Skręt, Andrzej |
author_facet | Raś, Renata Książek, Mariusz Barnaś, Edyta Skręt-Magierło, Joanna Kąziołka, Wojciech Fudali, Ludmiła Filipowska, Justyna Skręt, Andrzej |
author_sort | Raś, Renata |
collection | PubMed |
description | Benign metastasizing leiomyoma (BML) usually are situated in one organ, most often in lungs. BML patients typically have a history of uterine leiomyoma treated with hysterectomy, myomectomy or subtotal hysterectomy. The aim of the study was to present the case of a 53-year-old woman with triple location in the lungs, parametria and appendix. She had undergone a myomectomy 26 years earlier. In 2015, she was admitted to the surgical department because of abdominal pain, whereupon a cholecystectomy was performed. CT scans showed pelvic mass with pulmonary metastasis. Upon discharge the patient was referred to the Gynecology Clinic, where a laparotomy was performed. The intraoperative findings were: 1) uterus with multiple leiomyomas, 2) four tumors in the parametria, 3) tumor connected to the appendix. A subtotal hysterectomy, with a bilateral salpingo-oophorectomy, removal of the tumors from the parametria and appendectomy was performed. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining (strongly positive for estrogen receptors and SMA, while Ki67 was very low, below 1%). Upon postoperative recovery, the patient was referred to the Thoracic Surgery Department. During the thoracotomy, multiple nodes, surrounded by lung parenchyma, were revealed. Wedge resection was performed, for localized pulmonary lesions, and sent for pathological examination. The final pathological diagnosis was benign metastasizing leiomyomatosis. In conclusion, the triple location of BML could possibly be a result of a parallel different metastasizing mechanism, although it is impossible to exclude one mechanism, which may be the cause of the metastases in three locations. |
format | Online Article Text |
id | pubmed-4993987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-49939872016-08-31 Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix Raś, Renata Książek, Mariusz Barnaś, Edyta Skręt-Magierło, Joanna Kąziołka, Wojciech Fudali, Ludmiła Filipowska, Justyna Skręt, Andrzej Prz Menopauzalny Case Report Benign metastasizing leiomyoma (BML) usually are situated in one organ, most often in lungs. BML patients typically have a history of uterine leiomyoma treated with hysterectomy, myomectomy or subtotal hysterectomy. The aim of the study was to present the case of a 53-year-old woman with triple location in the lungs, parametria and appendix. She had undergone a myomectomy 26 years earlier. In 2015, she was admitted to the surgical department because of abdominal pain, whereupon a cholecystectomy was performed. CT scans showed pelvic mass with pulmonary metastasis. Upon discharge the patient was referred to the Gynecology Clinic, where a laparotomy was performed. The intraoperative findings were: 1) uterus with multiple leiomyomas, 2) four tumors in the parametria, 3) tumor connected to the appendix. A subtotal hysterectomy, with a bilateral salpingo-oophorectomy, removal of the tumors from the parametria and appendectomy was performed. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining (strongly positive for estrogen receptors and SMA, while Ki67 was very low, below 1%). Upon postoperative recovery, the patient was referred to the Thoracic Surgery Department. During the thoracotomy, multiple nodes, surrounded by lung parenchyma, were revealed. Wedge resection was performed, for localized pulmonary lesions, and sent for pathological examination. The final pathological diagnosis was benign metastasizing leiomyomatosis. In conclusion, the triple location of BML could possibly be a result of a parallel different metastasizing mechanism, although it is impossible to exclude one mechanism, which may be the cause of the metastases in three locations. Termedia Publishing House 2016-07-22 2016-06 /pmc/articles/PMC4993987/ /pubmed/27582687 http://dx.doi.org/10.5114/pm.2016.61195 Text en Copyright: © 2016 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Case Report Raś, Renata Książek, Mariusz Barnaś, Edyta Skręt-Magierło, Joanna Kąziołka, Wojciech Fudali, Ludmiła Filipowska, Justyna Skręt, Andrzej Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title | Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title_full | Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title_fullStr | Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title_full_unstemmed | Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title_short | Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
title_sort | benign metastasizing leiomyoma in triple location: lungs, parametria and appendix |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993987/ https://www.ncbi.nlm.nih.gov/pubmed/27582687 http://dx.doi.org/10.5114/pm.2016.61195 |
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