A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in...

Descripción completa

Detalles Bibliográficos
Autores principales: Grassilli, E, Pisano, F, Cialdella, A, Bonomo, S, Missaglia, C, Cerrito, M G, Masiero, L, Ianzano, L, Giordano, F, Cicirelli, V, Narloch, R, D'Amato, F, Noli, B, Ferri, G L, Leone, B E, Stanta, G, Bonin, S, Helin, K, Giovannoni, R, Lavitrano, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994017/
https://www.ncbi.nlm.nih.gov/pubmed/26804170
http://dx.doi.org/10.1038/onc.2015.504

Ejemplares similares

Ejemplares similares