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Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (medi...

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Autores principales: Sandoval-Alzate, Héctor Fabio, Agudelo-Zapata, Yessica, González-Clavijo, Angélica María, Poveda, Natalia E., Espinel-Pachón, Cristian Felipe, Escamilla-Castro, Jorge Augusto, Márquez-Julio, Heidy Lorena, Alvarado-Quintero, Hernando, Rojas-Rodríguez, Fabián Guillermo, Arteaga-Díaz, Juan Manuel, Eslava-Schmalbach, Javier Hernando, Garcés-Gutiérrez, Maria Fernanda, Vrontakis, Maria, Castaño, Justo P., Luque, Raul M., Diéguez, Carlos, Nogueiras, Rubén, Caminos, Jorge E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994037/
https://www.ncbi.nlm.nih.gov/pubmed/27550417
http://dx.doi.org/10.1038/srep31661
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author Sandoval-Alzate, Héctor Fabio
Agudelo-Zapata, Yessica
González-Clavijo, Angélica María
Poveda, Natalia E.
Espinel-Pachón, Cristian Felipe
Escamilla-Castro, Jorge Augusto
Márquez-Julio, Heidy Lorena
Alvarado-Quintero, Hernando
Rojas-Rodríguez, Fabián Guillermo
Arteaga-Díaz, Juan Manuel
Eslava-Schmalbach, Javier Hernando
Garcés-Gutiérrez, Maria Fernanda
Vrontakis, Maria
Castaño, Justo P.
Luque, Raul M.
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
author_facet Sandoval-Alzate, Héctor Fabio
Agudelo-Zapata, Yessica
González-Clavijo, Angélica María
Poveda, Natalia E.
Espinel-Pachón, Cristian Felipe
Escamilla-Castro, Jorge Augusto
Márquez-Julio, Heidy Lorena
Alvarado-Quintero, Hernando
Rojas-Rodríguez, Fabián Guillermo
Arteaga-Díaz, Juan Manuel
Eslava-Schmalbach, Javier Hernando
Garcés-Gutiérrez, Maria Fernanda
Vrontakis, Maria
Castaño, Justo P.
Luque, Raul M.
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
author_sort Sandoval-Alzate, Héctor Fabio
collection PubMed
description Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.
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spelling pubmed-49940372016-08-30 Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test Sandoval-Alzate, Héctor Fabio Agudelo-Zapata, Yessica González-Clavijo, Angélica María Poveda, Natalia E. Espinel-Pachón, Cristian Felipe Escamilla-Castro, Jorge Augusto Márquez-Julio, Heidy Lorena Alvarado-Quintero, Hernando Rojas-Rodríguez, Fabián Guillermo Arteaga-Díaz, Juan Manuel Eslava-Schmalbach, Javier Hernando Garcés-Gutiérrez, Maria Fernanda Vrontakis, Maria Castaño, Justo P. Luque, Raul M. Diéguez, Carlos Nogueiras, Rubén Caminos, Jorge E. Sci Rep Article Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT. Nature Publishing Group 2016-08-23 /pmc/articles/PMC4994037/ /pubmed/27550417 http://dx.doi.org/10.1038/srep31661 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sandoval-Alzate, Héctor Fabio
Agudelo-Zapata, Yessica
González-Clavijo, Angélica María
Poveda, Natalia E.
Espinel-Pachón, Cristian Felipe
Escamilla-Castro, Jorge Augusto
Márquez-Julio, Heidy Lorena
Alvarado-Quintero, Hernando
Rojas-Rodríguez, Fabián Guillermo
Arteaga-Díaz, Juan Manuel
Eslava-Schmalbach, Javier Hernando
Garcés-Gutiérrez, Maria Fernanda
Vrontakis, Maria
Castaño, Justo P.
Luque, Raul M.
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title_full Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title_fullStr Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title_full_unstemmed Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title_short Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test
title_sort serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994037/
https://www.ncbi.nlm.nih.gov/pubmed/27550417
http://dx.doi.org/10.1038/srep31661
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