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Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila

Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separat...

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Autores principales: Kundu, Srikanya, Ganguly, Anindya, Chakraborty, Tuhin Subhra, Kumar, Arun, Siddiqi, Obaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994066/
https://www.ncbi.nlm.nih.gov/pubmed/27588303
http://dx.doi.org/10.1523/ENEURO.0056-14.2016
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author Kundu, Srikanya
Ganguly, Anindya
Chakraborty, Tuhin Subhra
Kumar, Arun
Siddiqi, Obaid
author_facet Kundu, Srikanya
Ganguly, Anindya
Chakraborty, Tuhin Subhra
Kumar, Arun
Siddiqi, Obaid
author_sort Kundu, Srikanya
collection PubMed
description Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separately or treats mixtures as different entities is not well understood. Using Drosophila melanogaster as a model system, we have demonstrated that fruit flies perceive binary odor mixtures in a manner that is heavily dependent on both the proportion and the degree of dilution of the components, suggesting a combinatorial coding at the peripheral level. This coding strategy appears to be receptor specific and is independent of interneuronal interactions.
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spelling pubmed-49940662016-09-01 Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila Kundu, Srikanya Ganguly, Anindya Chakraborty, Tuhin Subhra Kumar, Arun Siddiqi, Obaid eNeuro New Research Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separately or treats mixtures as different entities is not well understood. Using Drosophila melanogaster as a model system, we have demonstrated that fruit flies perceive binary odor mixtures in a manner that is heavily dependent on both the proportion and the degree of dilution of the components, suggesting a combinatorial coding at the peripheral level. This coding strategy appears to be receptor specific and is independent of interneuronal interactions. Society for Neuroscience 2016-08-23 /pmc/articles/PMC4994066/ /pubmed/27588303 http://dx.doi.org/10.1523/ENEURO.0056-14.2016 Text en Copyright © 2016 Kundu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Kundu, Srikanya
Ganguly, Anindya
Chakraborty, Tuhin Subhra
Kumar, Arun
Siddiqi, Obaid
Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title_full Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title_fullStr Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title_full_unstemmed Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title_short Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
title_sort synergism and combinatorial coding for binary odor mixture perception in drosophila
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994066/
https://www.ncbi.nlm.nih.gov/pubmed/27588303
http://dx.doi.org/10.1523/ENEURO.0056-14.2016
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