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Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila
Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994066/ https://www.ncbi.nlm.nih.gov/pubmed/27588303 http://dx.doi.org/10.1523/ENEURO.0056-14.2016 |
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author | Kundu, Srikanya Ganguly, Anindya Chakraborty, Tuhin Subhra Kumar, Arun Siddiqi, Obaid |
author_facet | Kundu, Srikanya Ganguly, Anindya Chakraborty, Tuhin Subhra Kumar, Arun Siddiqi, Obaid |
author_sort | Kundu, Srikanya |
collection | PubMed |
description | Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separately or treats mixtures as different entities is not well understood. Using Drosophila melanogaster as a model system, we have demonstrated that fruit flies perceive binary odor mixtures in a manner that is heavily dependent on both the proportion and the degree of dilution of the components, suggesting a combinatorial coding at the peripheral level. This coding strategy appears to be receptor specific and is independent of interneuronal interactions. |
format | Online Article Text |
id | pubmed-4994066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-49940662016-09-01 Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila Kundu, Srikanya Ganguly, Anindya Chakraborty, Tuhin Subhra Kumar, Arun Siddiqi, Obaid eNeuro New Research Most odors in the natural environment are mixtures of several compounds. Olfactory receptors housed in the olfactory sensory neurons detect these odors and transmit the information to the brain, leading to decision-making. But whether the olfactory system detects the ingredients of a mixture separately or treats mixtures as different entities is not well understood. Using Drosophila melanogaster as a model system, we have demonstrated that fruit flies perceive binary odor mixtures in a manner that is heavily dependent on both the proportion and the degree of dilution of the components, suggesting a combinatorial coding at the peripheral level. This coding strategy appears to be receptor specific and is independent of interneuronal interactions. Society for Neuroscience 2016-08-23 /pmc/articles/PMC4994066/ /pubmed/27588303 http://dx.doi.org/10.1523/ENEURO.0056-14.2016 Text en Copyright © 2016 Kundu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Kundu, Srikanya Ganguly, Anindya Chakraborty, Tuhin Subhra Kumar, Arun Siddiqi, Obaid Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title | Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title_full | Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title_fullStr | Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title_full_unstemmed | Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title_short | Synergism and Combinatorial Coding for Binary Odor Mixture Perception in Drosophila |
title_sort | synergism and combinatorial coding for binary odor mixture perception in drosophila |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994066/ https://www.ncbi.nlm.nih.gov/pubmed/27588303 http://dx.doi.org/10.1523/ENEURO.0056-14.2016 |
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