Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?

BACKGROUND: Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) a...

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Autores principales: Frau, J., Cossu, D., Sardu, C., Mameli, G., Coghe, G., Lorefice, L., Fenu, G., Tranquilli, S., Sechi, L. A., Marrosu, M. G., Cocco, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994163/
https://www.ncbi.nlm.nih.gov/pubmed/27552900
http://dx.doi.org/10.1186/s12883-016-0669-1
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author Frau, J.
Cossu, D.
Sardu, C.
Mameli, G.
Coghe, G.
Lorefice, L.
Fenu, G.
Tranquilli, S.
Sechi, L. A.
Marrosu, M. G.
Cocco, E.
author_facet Frau, J.
Cossu, D.
Sardu, C.
Mameli, G.
Coghe, G.
Lorefice, L.
Fenu, G.
Tranquilli, S.
Sechi, L. A.
Marrosu, M. G.
Cocco, E.
author_sort Frau, J.
collection PubMed
description BACKGROUND: Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. METHODS: Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective. RESULTS: Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p = 0.04). CONCLUSIONS: We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.
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spelling pubmed-49941632016-08-24 Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors? Frau, J. Cossu, D. Sardu, C. Mameli, G. Coghe, G. Lorefice, L. Fenu, G. Tranquilli, S. Sechi, L. A. Marrosu, M. G. Cocco, E. BMC Neurol Research Article BACKGROUND: Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. METHODS: Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective. RESULTS: Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p = 0.04). CONCLUSIONS: We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP. BioMed Central 2016-08-23 /pmc/articles/PMC4994163/ /pubmed/27552900 http://dx.doi.org/10.1186/s12883-016-0669-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Frau, J.
Cossu, D.
Sardu, C.
Mameli, G.
Coghe, G.
Lorefice, L.
Fenu, G.
Tranquilli, S.
Sechi, L. A.
Marrosu, M. G.
Cocco, E.
Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title_full Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title_fullStr Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title_full_unstemmed Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title_short Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
title_sort combining hla-drb1-dqb1 and mycobacterium avium subspecies paratubercolosis (map) antibodies in sardinian multiple sclerosis patients: associated or independent risk factors?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994163/
https://www.ncbi.nlm.nih.gov/pubmed/27552900
http://dx.doi.org/10.1186/s12883-016-0669-1
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