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Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury

BACKGROUND: Microglia/macrophages play a critical role in the inflammatory and immune processes of cerebral ischemia/reperfusion injury. Since microglia/macrophages can reversibly shift their phenotype toward either a “detrimental” or a “restorative” state in the injured central nervous system (CNS)...

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Detalles Bibliográficos
Autores principales:	Wang, Po, He, Yating, Li, Daojing, Han, Ranran, Liu, Guiyou, Kong, Dexin, Hao, Junwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994222/ https://www.ncbi.nlm.nih.gov/pubmed/27549161 http://dx.doi.org/10.1186/s12974-016-0660-1

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