4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

BACKGROUND: Sigma (σ) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents. Sigma receptors...

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Detalles Bibliográficos
Autores principales: Ikome, Hermia N., Ntie-Kang, Fidele, Ngemenya, Moses N., Tu, Zhude, Mach, Robert H., Efange, Simon M. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994268/
https://www.ncbi.nlm.nih.gov/pubmed/27555879
http://dx.doi.org/10.1186/s13065-016-0200-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994268/
https://www.ncbi.nlm.nih.gov/pubmed/27555879
http://dx.doi.org/10.1186/s13065-016-0200-1

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