Mutation in West Nile Virus Structural Protein prM during Human Infection

A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates activ...

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Detalles Bibliográficos
Autores principales: Lustig, Yaniv, Lanciotti, Robert S., Hindiyeh, Musa, Keller, Nathan, Milo, Ron, Mayan, Shlomo, Mendelson, Ella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994336/
https://www.ncbi.nlm.nih.gov/pubmed/27322782
http://dx.doi.org/10.3201/eid2209.160132
Descripción
Sumario:A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.

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