Mutation in West Nile Virus Structural Protein prM during Human Infection

A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates activ...

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Detalles Bibliográficos
Autores principales: Lustig, Yaniv, Lanciotti, Robert S., Hindiyeh, Musa, Keller, Nathan, Milo, Ron, Mayan, Shlomo, Mendelson, Ella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994336/
https://www.ncbi.nlm.nih.gov/pubmed/27322782
http://dx.doi.org/10.3201/eid2209.160132
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author Lustig, Yaniv
Lanciotti, Robert S.
Hindiyeh, Musa
Keller, Nathan
Milo, Ron
Mayan, Shlomo
Mendelson, Ella
author_facet Lustig, Yaniv
Lanciotti, Robert S.
Hindiyeh, Musa
Keller, Nathan
Milo, Ron
Mayan, Shlomo
Mendelson, Ella
author_sort Lustig, Yaniv
collection PubMed
description A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.
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spelling pubmed-49943362016-09-08 Mutation in West Nile Virus Structural Protein prM during Human Infection Lustig, Yaniv Lanciotti, Robert S. Hindiyeh, Musa Keller, Nathan Milo, Ron Mayan, Shlomo Mendelson, Ella Emerg Infect Dis Dispatch A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient’s urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection. Centers for Disease Control and Prevention 2016-09 /pmc/articles/PMC4994336/ /pubmed/27322782 http://dx.doi.org/10.3201/eid2209.160132 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Lustig, Yaniv
Lanciotti, Robert S.
Hindiyeh, Musa
Keller, Nathan
Milo, Ron
Mayan, Shlomo
Mendelson, Ella
Mutation in West Nile Virus Structural Protein prM during Human Infection
title Mutation in West Nile Virus Structural Protein prM during Human Infection
title_full Mutation in West Nile Virus Structural Protein prM during Human Infection
title_fullStr Mutation in West Nile Virus Structural Protein prM during Human Infection
title_full_unstemmed Mutation in West Nile Virus Structural Protein prM during Human Infection
title_short Mutation in West Nile Virus Structural Protein prM during Human Infection
title_sort mutation in west nile virus structural protein prm during human infection
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994336/
https://www.ncbi.nlm.nih.gov/pubmed/27322782
http://dx.doi.org/10.3201/eid2209.160132
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