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Ebola Virus Disease, Democratic Republic of the Congo, 2014

During July–November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients...

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Autores principales: Nanclares, Carolina, Kapetshi, Jimmy, Lionetto, Fanshen, de la Rosa, Olimpia, Tamfun, Jean-Jacques Muyembe, Alia, Miriam, Kobinger, Gary, Bernasconi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994351/
https://www.ncbi.nlm.nih.gov/pubmed/27533284
http://dx.doi.org/10.3201/eid2209.160354
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author Nanclares, Carolina
Kapetshi, Jimmy
Lionetto, Fanshen
de la Rosa, Olimpia
Tamfun, Jean-Jacques Muyembe
Alia, Miriam
Kobinger, Gary
Bernasconi, Andrea
author_facet Nanclares, Carolina
Kapetshi, Jimmy
Lionetto, Fanshen
de la Rosa, Olimpia
Tamfun, Jean-Jacques Muyembe
Alia, Miriam
Kobinger, Gary
Bernasconi, Andrea
author_sort Nanclares, Carolina
collection PubMed
description During July–November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
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spelling pubmed-49943512016-09-08 Ebola Virus Disease, Democratic Republic of the Congo, 2014 Nanclares, Carolina Kapetshi, Jimmy Lionetto, Fanshen de la Rosa, Olimpia Tamfun, Jean-Jacques Muyembe Alia, Miriam Kobinger, Gary Bernasconi, Andrea Emerg Infect Dis Research During July–November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control. Centers for Disease Control and Prevention 2016-09 /pmc/articles/PMC4994351/ /pubmed/27533284 http://dx.doi.org/10.3201/eid2209.160354 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Nanclares, Carolina
Kapetshi, Jimmy
Lionetto, Fanshen
de la Rosa, Olimpia
Tamfun, Jean-Jacques Muyembe
Alia, Miriam
Kobinger, Gary
Bernasconi, Andrea
Ebola Virus Disease, Democratic Republic of the Congo, 2014
title Ebola Virus Disease, Democratic Republic of the Congo, 2014
title_full Ebola Virus Disease, Democratic Republic of the Congo, 2014
title_fullStr Ebola Virus Disease, Democratic Republic of the Congo, 2014
title_full_unstemmed Ebola Virus Disease, Democratic Republic of the Congo, 2014
title_short Ebola Virus Disease, Democratic Republic of the Congo, 2014
title_sort ebola virus disease, democratic republic of the congo, 2014
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994351/
https://www.ncbi.nlm.nih.gov/pubmed/27533284
http://dx.doi.org/10.3201/eid2209.160354
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