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Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities

Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks o...

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Autores principales: Baker, Kate S., Dallman, Timothy J., Behar, Adi, Weill, François-Xavier, Gouali, Malika, Sobel, Jeremy, Fookes, Maria, Valinsky, Lea, Gal-Mor, Ohad, Connor, Thomas R., Nissan, Israel, Bertrand, Sophie, Parkhill, Julian, Jenkins, Claire, Cohen, Dani, Thomson, Nicholas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994374/
https://www.ncbi.nlm.nih.gov/pubmed/27532625
http://dx.doi.org/10.3201/eid2209.151953
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author Baker, Kate S.
Dallman, Timothy J.
Behar, Adi
Weill, François-Xavier
Gouali, Malika
Sobel, Jeremy
Fookes, Maria
Valinsky, Lea
Gal-Mor, Ohad
Connor, Thomas R.
Nissan, Israel
Bertrand, Sophie
Parkhill, Julian
Jenkins, Claire
Cohen, Dani
Thomson, Nicholas R.
author_facet Baker, Kate S.
Dallman, Timothy J.
Behar, Adi
Weill, François-Xavier
Gouali, Malika
Sobel, Jeremy
Fookes, Maria
Valinsky, Lea
Gal-Mor, Ohad
Connor, Thomas R.
Nissan, Israel
Bertrand, Sophie
Parkhill, Julian
Jenkins, Claire
Cohen, Dani
Thomson, Nicholas R.
author_sort Baker, Kate S.
collection PubMed
description Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
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spelling pubmed-49943742016-09-08 Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities Baker, Kate S. Dallman, Timothy J. Behar, Adi Weill, François-Xavier Gouali, Malika Sobel, Jeremy Fookes, Maria Valinsky, Lea Gal-Mor, Ohad Connor, Thomas R. Nissan, Israel Bertrand, Sophie Parkhill, Julian Jenkins, Claire Cohen, Dani Thomson, Nicholas R. Emerg Infect Dis Research Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities. Centers for Disease Control and Prevention 2016-09 /pmc/articles/PMC4994374/ /pubmed/27532625 http://dx.doi.org/10.3201/eid2209.151953 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Baker, Kate S.
Dallman, Timothy J.
Behar, Adi
Weill, François-Xavier
Gouali, Malika
Sobel, Jeremy
Fookes, Maria
Valinsky, Lea
Gal-Mor, Ohad
Connor, Thomas R.
Nissan, Israel
Bertrand, Sophie
Parkhill, Julian
Jenkins, Claire
Cohen, Dani
Thomson, Nicholas R.
Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title_full Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title_fullStr Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title_full_unstemmed Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title_short Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
title_sort travel- and community-based transmission of multidrug-resistant shigella sonnei lineage among international orthodox jewish communities
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994374/
https://www.ncbi.nlm.nih.gov/pubmed/27532625
http://dx.doi.org/10.3201/eid2209.151953
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