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Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities
Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks o...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994374/ https://www.ncbi.nlm.nih.gov/pubmed/27532625 http://dx.doi.org/10.3201/eid2209.151953 |
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author | Baker, Kate S. Dallman, Timothy J. Behar, Adi Weill, François-Xavier Gouali, Malika Sobel, Jeremy Fookes, Maria Valinsky, Lea Gal-Mor, Ohad Connor, Thomas R. Nissan, Israel Bertrand, Sophie Parkhill, Julian Jenkins, Claire Cohen, Dani Thomson, Nicholas R. |
author_facet | Baker, Kate S. Dallman, Timothy J. Behar, Adi Weill, François-Xavier Gouali, Malika Sobel, Jeremy Fookes, Maria Valinsky, Lea Gal-Mor, Ohad Connor, Thomas R. Nissan, Israel Bertrand, Sophie Parkhill, Julian Jenkins, Claire Cohen, Dani Thomson, Nicholas R. |
author_sort | Baker, Kate S. |
collection | PubMed |
description | Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities. |
format | Online Article Text |
id | pubmed-4994374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-49943742016-09-08 Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities Baker, Kate S. Dallman, Timothy J. Behar, Adi Weill, François-Xavier Gouali, Malika Sobel, Jeremy Fookes, Maria Valinsky, Lea Gal-Mor, Ohad Connor, Thomas R. Nissan, Israel Bertrand, Sophie Parkhill, Julian Jenkins, Claire Cohen, Dani Thomson, Nicholas R. Emerg Infect Dis Research Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug–resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities. Centers for Disease Control and Prevention 2016-09 /pmc/articles/PMC4994374/ /pubmed/27532625 http://dx.doi.org/10.3201/eid2209.151953 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Baker, Kate S. Dallman, Timothy J. Behar, Adi Weill, François-Xavier Gouali, Malika Sobel, Jeremy Fookes, Maria Valinsky, Lea Gal-Mor, Ohad Connor, Thomas R. Nissan, Israel Bertrand, Sophie Parkhill, Julian Jenkins, Claire Cohen, Dani Thomson, Nicholas R. Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities |
title | Travel- and Community-Based Transmission of Multidrug-Resistant
Shigella
sonnei Lineage among International Orthodox Jewish
Communities |
title_full | Travel- and Community-Based Transmission of Multidrug-Resistant
Shigella
sonnei Lineage among International Orthodox Jewish
Communities |
title_fullStr | Travel- and Community-Based Transmission of Multidrug-Resistant
Shigella
sonnei Lineage among International Orthodox Jewish
Communities |
title_full_unstemmed | Travel- and Community-Based Transmission of Multidrug-Resistant
Shigella
sonnei Lineage among International Orthodox Jewish
Communities |
title_short | Travel- and Community-Based Transmission of Multidrug-Resistant
Shigella
sonnei Lineage among International Orthodox Jewish
Communities |
title_sort | travel- and community-based transmission of multidrug-resistant
shigella
sonnei lineage among international orthodox jewish
communities |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994374/ https://www.ncbi.nlm.nih.gov/pubmed/27532625 http://dx.doi.org/10.3201/eid2209.151953 |
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