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Chronic allograft rejection: A significant hurdle to transplant success

The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation. This form of rejection is responsible for long-term failure of transplanted organs. The mechanisms involved in de...

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Detalles Bibliográficos
Autores principales: Kloc, Malgorzata, Ghobrial, Rafik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994504/
https://www.ncbi.nlm.nih.gov/pubmed/27574640
http://dx.doi.org/10.4103/2321-3868.121646
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author Kloc, Malgorzata
Ghobrial, Rafik M.
author_facet Kloc, Malgorzata
Ghobrial, Rafik M.
author_sort Kloc, Malgorzata
collection PubMed
description The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation. This form of rejection is responsible for long-term failure of transplanted organs. The mechanisms involved in development of chronic rejection are not well-understood. One of the main features of chronic rejection is progressive luminal narrowing of graft vessels, which results in compromised blood flow, ischemia, cell death, and finally graft failure. All the existing immunosuppressive regimens are targeting acute rejection, and at present there is no available therapy for prevention of chronic rejection. Chronic rejection involves two major, but interrelated responses: The first is the host immune response against the transplant mediated primarily by alloreactive T and B cells, and the second is injury and repair of the graft (vasculopathy of graft vessels). Here we focus on recent advances in understanding the cellular and molecular aspects of chronic transplant vasculopathy and function of macrophages, topics pivotal for development of novel antichronic rejection therapies.
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spelling pubmed-49945042016-08-29 Chronic allograft rejection: A significant hurdle to transplant success Kloc, Malgorzata Ghobrial, Rafik M. Burns Trauma Review Article The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation. This form of rejection is responsible for long-term failure of transplanted organs. The mechanisms involved in development of chronic rejection are not well-understood. One of the main features of chronic rejection is progressive luminal narrowing of graft vessels, which results in compromised blood flow, ischemia, cell death, and finally graft failure. All the existing immunosuppressive regimens are targeting acute rejection, and at present there is no available therapy for prevention of chronic rejection. Chronic rejection involves two major, but interrelated responses: The first is the host immune response against the transplant mediated primarily by alloreactive T and B cells, and the second is injury and repair of the graft (vasculopathy of graft vessels). Here we focus on recent advances in understanding the cellular and molecular aspects of chronic transplant vasculopathy and function of macrophages, topics pivotal for development of novel antichronic rejection therapies. BioMed Central 2014-01-26 /pmc/articles/PMC4994504/ /pubmed/27574640 http://dx.doi.org/10.4103/2321-3868.121646 Text en © Author 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
spellingShingle Review Article
Kloc, Malgorzata
Ghobrial, Rafik M.
Chronic allograft rejection: A significant hurdle to transplant success
title Chronic allograft rejection: A significant hurdle to transplant success
title_full Chronic allograft rejection: A significant hurdle to transplant success
title_fullStr Chronic allograft rejection: A significant hurdle to transplant success
title_full_unstemmed Chronic allograft rejection: A significant hurdle to transplant success
title_short Chronic allograft rejection: A significant hurdle to transplant success
title_sort chronic allograft rejection: a significant hurdle to transplant success
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994504/
https://www.ncbi.nlm.nih.gov/pubmed/27574640
http://dx.doi.org/10.4103/2321-3868.121646
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