Affinity for self antigen selects regulatory T cells with distinct functional properties

How regulatory T cells (T(reg) cell) control lymphocyte homeostasis is not fully understood. Here we identify two T(reg) cell populations with differing degrees of self-reactivity and distinct regulatory functions. Triple(hi) (GITR(hi)PD-1(hi)CD25(hi)) T(reg) cell are highly self-reactive and contro...

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Detalles Bibliográficos
Autores principales: Wyss, Lena, Stadinski, Brian D., King, Carolyn G., Schallenberg, Sonja, McCarthy, Nicholas I., Lee, Jun Young, Kretschmer, Karsten, Terracciano, Luigi M., Anderson, Graham, Surh, Charles D., Huseby, Eric S., Palmer, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994872/
https://www.ncbi.nlm.nih.gov/pubmed/27478940
http://dx.doi.org/10.1038/ni.3522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994872/
https://www.ncbi.nlm.nih.gov/pubmed/27478940
http://dx.doi.org/10.1038/ni.3522

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